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Isotonix OPC-3® Prime NAD+ Isotonix® Magnesium

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How Prime Anti-Aging Nutraceuticals® NAD+ Benefits You


Unlock the secret to healthy aging and vitality with Prime Anti-Aging Nutraceuticals® NAD+.

Cutting-edge science that renews cells and DNA so you are energized, mentally sharp, and look and feel younger. Whether fighting aging or coping with a demanding lifestyle, reclaim your spark and thrive with Prime NAD+!

Just as atoms form the foundation of the universe, cells are the building blocks of our bodies, and at the core of cellular health lies nicotinamide adenine dinucleotide (NAD): an essential coenzyme for carrying out cellular and metabolic functions. Prime NAD+ harnesses the power of science to deliver 250 mg of nicotinamide riboside (NR) and 50 mg of the NAD precursor, pterostilbene, scientifically proven to support NAD levels within your cells. NAD is the key to maintaining optimal cellular metabolism, energy production and youthful vigor. Whether you're combating age-related NAD decline or tackling the challenges of a demanding lifestyle, Prime NAD+ is your ally in sustaining a healthy reservoir of this vital molecule. It's time to take control of your energy reserve and support a better you. Forget age; take back your vitality with Prime NAD+.



Primary Benefits* of Prime NAD+


Combats aging at the cellular level.

  • Supports healthy NAD production
  • Promotes normal activity of SIRT-1 gene
  • Supports healthy mitochondrial function
  • Helps maintain healthy levels of ATP production within the cell
  • May help combat the cellular aging process
  • May help maintain NAD levels in aging adults
  • Helps to maintain neurological and cognitive health as we age
  • Supports cellular health
  • Support healthy cellular metabolism
  • Supports healthy cognitive function
  • Powerful antioxidant
  • Protects the body from the negative effects of free radicals


Primary Benefits* of Prime NAD+

Fountain of Youth


What Makes Prime NAD+ Unique?


Much like an atom is the foundation of the universe, a cell is the foundation of the human body. In the quest for long life and optimal health, scientists have delved into the intricate world of cellular function, DNA integrity and energy production. One significant compound stands out amongst the rest as being a crucial part of human metabolism and its aging process: nicotinamide adenine dinucleotide (NAD). Whether we are talking about simple bacteria or the complexity of human metabolism, NAD and its metabolic counterpart NADH are what the cell relies on for life.

These compounds hold the key to supporting healthy metabolism and aging. NAD is a coenzyme that is essential for carrying out cellular and metabolic functions, such as maintaining healthy levels of ATP production within the cells, supporting the body’s cellular regeneration process and supporting healthy mitochondrial metabolism. Prime NAD+ delivers 250 mg of nicotinamide riboside (NR), paired with 50 mg of pterostilbene, both of which have been scientifically shown to support NAD levels within our cells. NAD is connected to one’s health, youth and quality of life; you simply cannot live without it since it is essential for cellular life. The youth of our cells is associated with our physical and cognitive health and overall well-being. Prime NAD+ is a powerful gluten-free, non-GMO, cutting-edge formula that works to support healthy NAD production and helps maintain NAD levels in aging adults and adults with demanding fitness, work and travel schedules. If it feels like time is always running against you, it's time to consider your energy reserve and NAD. Whether you are looking to combat the natural age-related decline of NAD levels or support NAD levels for those living NAD-depleting lifestyles, the ultimate goal of Prime NAD+ is helping you sustain a healthy reservoir of the youthful NAD molecule.

NAD is naturally occurring; it resides in every living cell in the body and has been shown to be strongly linked to keeping one's youth. Various sources of vitamin B3 are known as precursors of NAD, meaning they influence or help build upon the production of NAD. The balance between the consumption and synthesis of NAD plays into the replenishment or concentration levels of NAD within our cells. There are three pathways that are responsible for helping to maintain this balance, with each one working differently to convert NAD precursors into NAD for our cells. Prime NAD+ is specifically formulated with NR; this precursor is linked to the salvage pathway which plays a unique role in replenishing or restoring the pools of NAD in our cells. NAD+, the oxidized form of nicotinamide adenine dinucleotides, and NADH, the reduced form, make up the NAD+/NADH redox ratio, which provides insight as to how well our cells are creating energy or ATP and portrays the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio, throwing it off balance, and imbalances of this ratio are associated with cellular aging. Consuming more NAD precursors that promote the increase of NAD is the longevity secret for helping to maintain a healthy balance of this ratio.

Younger people naturally have higher levels of NAD pools in their cells. Additionally, observational research shows that older individuals who do not display the same biomarkers of aging as their age group are also correlated with higher pools of NAD. This demonstrates why sufficient levels are correlated with cell youth and longevity. Studies have shown that the body’s natural NAD production begins to first decrease in skin and within the brain as we age, making these precursors of higher importance to help sustain NAD levels. Other cellular pools also are impacted by age and the loss of NAD; such as mitochondria, adipose tissue and muscle- emphasizing that NAD is a crucial part of healthy aging. Prime NAD+ is formulated with two powerful ingredients, NR and pterostilbene, both of which have scientifically proven their ability to support cellular health. A study analyzing the effects of taking both the precursor NR and pterostilbene for an eight-week period (in which participants were either administered a placebo, a single serving or a double serving of the recommended amount) demonstrated its ability promote an increase of NAD levels. When analyzing concentration of NAD levels in the participants’ blood after four weeks, the study found that the group who took the recommended serving showed a 40% increase and the group who was administered a double serving showed a 90% increase of NAD levels in the blood; the placebo group showed no change. In addition, the levels reported at four weeks remained consistent for both groups who were administered NR and pterostilbene supplementation when measured at 60 days.

While supplementation of NAD precursors is what promotes an extra reserve of NAD, it is NAD itself that really does the heavy lifting and influences all the different working parts of the cell that safeguard you from the inevitable cellular aging process. One influencing factor is the promotion of sirtuins (SIRTs) activity, also known as the “longevity genes.” These genes are enzymes that assist in cellular metabolism and help protect the cells’ state of equilibrium or balance when the cells encounter stress. Prime NAD+ promotes the normal activity of the SIRT-1 gene, a treasured gene that protects the body from the negative effects of free radicals. SIRT-1 is associated with the anti-aging pathways, longevity and the modulation of a whirlwind of processes including DNA repair, genome maintenance, mitochondrial functioning and cellular metabolism. When our DNA becomes damaged, it can deplete the cell’s NAD levels, leading to a decrease in sirtuin activity. Therefore, stockpiling a healthy savings account of NAD naturally makes it easier for our cells to detoxify and aids in preserving the integrity of our genetic blueprint for optimal health.

While maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the of telomeres. Telomeres are genome-protective caps located at the end of chromosomes: they act like the clear coating at the end of a shoelace string that keeps the shoelace from fraying. These little caps can indicate the age or suggested lifespan of a cell, in which the longer in length the telomere is, the better. Each time your cells divide, the chromosomal telomeres become shortened, and over time they inevitably reach the point where the cell can no longer replicate. Evidence shows that shorter telomeres contain lower NAD levels. Just as NAD levels decrease with age, telomeres naturally shorten with age and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process. Studies suggest that taking both NR and pterostilbene together can support each other's bioavailability, or their ability to be absorbed by the cells. The bioavailability of pterostilbene is an essential factor that promotes the normal activity of the SIRT-1 gene. Pterostilbene also acts as the golden sword for the aging mind, as the autophagy-influencing antioxidant supports the mediation of SIRT-1 and SIRT-2, which may help maintain neurological and cognitive health. In addition, pterostilbene has been shown to be 60% more bioavailable and has a 91 minute longer half-life than its well-known stilbene counterpart, resveratrol; this means that pterostilbene is actively working in your system to assist the cells for a longer period.

Regardless of age, practicing poor lifestyle habits such as smoking, drinking alcohol, lack of sleep or exercise, unhealthy diets and other factors can have depleting effects on maintaining an optimal reservoir of NAD, making NAD-promoting supplementation beneficial for even those who are considered to be younger than the age when metabolic energy may naturally begin to slow down. NR and pterostilbene offer a treasure trove of benefits for our overall well-being and bring you one step further to helping you hack the aging process. With Prime NAD+ on your side, “The golden age is before us, not behind us.” You don’t have to wait until you are aged to start caring about aging.

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure, or prevent any disease.



Product Classifications


Quality Standards – GMP Operations and Standardized Ingredients

Checked For – Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency and Identity

Gluten-Free – The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs – The finished product contains no detectable genetically-modified organisms.

Vegan – The product is made without ingredients produced or derived from animals.



Key Ingredients


Nicotinamide Riboside (crystalline nicotinamide riboside chloride)
Nicotinamide adenine dinucleotide (NAD) levels naturally decline as we age, and lower levels have been linked to various health issues and the aging process itself. Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD. When consumed, NR undergoes a series of biochemical reactions, transforming into nicotinamide mononucleotide (NMN), which the body then readily converts into NAD. NAD is a critical coenzyme found in every cell of the body. Its role is to act as a shuttle bus, carrying electrons between molecules in essential steps for many metabolic processes within the cell, namely ATP production – the energy source fueling various cellular functions.

Pterostilbene
Pterostilbene is a naturally occurring compound synthesized in plants. It has a similar structure to the more well-known phenol resveratrol. However, pterostilbene has a longer half-life and the compound has two methoxy groups, giving it a higher bioavailability than resveratrol. Once ingested, it is absorbed into the bloodstream and interacts with various cells and tissues, assisting in several biological pathways. Like resveratrol, pterostilbene has been shown to exhibit antioxidant properties, helping to neutralize harmful free radicals and oxidative stress.



FAQs


  1. What are the directions of use for this product?
    Adults, take 2 capsules every morning with or without food. This supplement is meant to be taken only once a day.

  2. Are there any warnings for this product?
    If you are currently using any prescription drugs or have an ongoing medical condition, consult your healthcare provider before using this product. Do not take this product if you are pregnant or breastfeeding.

  3. What are the two factors that play into the continuous replenishment of NAD in the cells?
    The consumption and synthesis of NAD are two factors that play into the replenishment or concentration levels of NAD within the cells. There are three pathways that are responsible for helping to maintain this balance, known as the Preiss-Handler pathway, de novo biosynthesis pathway and the salvage pathway. Each of these pathways works in different ways to help the precursor NR and other NAD precursors convert into NAD for the body’s cells. The NAD precursor NR is specifically linked to the salvage pathway.

  4. What is NAD+/NADH redox ratio?
    NAD+ is recognized as the oxidized form of nicotinamide adenine dinucleotides whereas NADH is the reduced form. Overall, the NAD+/NADH redox ratio explains how well the cells are creating energy or ATP, portraying the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio, throwing it off balance and leading to a decreased ratio which is also associated with age. Consuming more NAD precursors which help support levels of NAD is effective for helping to maintain a healthy balance of this ratio.

  5. What can deplete NAD levels in the body other than aging?
    Regardless of age, rough lifestyle habits can contribute to the increased need of NAD. Smoking, alcohol consumption, not exercising, being overweight, getting an inadequate amount of sleep and eating an unhealthy diet are all factors that can lead to NAD depletion.

  6. Is this product vegetarian or vegan?
    This product contains no animal-derived ingredients and is suitable for vegetarians and vegans.

  7. How does Prime NAD+ differ from Heart Health™ Advanced Co-Q10 on a cellular level and Awake® Energy Shot on an energy level?
    With age, the body produces less Co-Q10 naturally; Heart Health Advanced Co-Q10 provides additional Co-Q10 to the body which helps generate energy in every cell of the human body and promotes cardiovascular health. Awake Energy Shot is formulated with B vitamins and caffeine to provide a quick boost or bump of energy when needed. Prime NAD+ is not a short-lived type of energy supplement but an energy supplement for cellular longevity and vitality.

  8. What are NAD precursors?
    Various sources of vitamin B3, including nicotinamide riboside (NR), nicotinic acid (NA), nicotinamide (NAM), nicotinamide mononucleotide (NMN), and tryptophan (Trp), are known as precursors of NAD, meaning they influence or help build upon the production of NAD.

  9. What is the half-life of pterostilbene in comparison to resveratrol?
    Pterostilbene has a much longer half-life (105 minutes) than resveratrol (14 minutes), meaning that pterostilbene is actively working in your system for a longer time.

  10. How do Prime NAD+ and Heart Health Advanced Co-Q10 work differently to support cell functioning?
    NAD is the spark that initiates what is called electron-transport chain, which is required to manufacture adenosine triphosphate (ATP) or the energy currency of our cells; it is cellular energy at its core and the spark of human metabolism. Heart Health Advanced Co-Q10 contains coenzyme Q10, which acts as a necessary fuel product to support mitochondrial generation. Co-Q10 safeguards the mitochondria from oxidative stress and helps create a healthy environment for mitochondrial activity. In short, NAD is the literal spark for energy, where Co-Q10 is the fuel.

  11. What are other ways you can promote sirtuin activity?
    Sirtuins are special molecules that are associated with supporting the cells’ lifespan. In addition to NR and pterostilbene, the youthful, antioxidant-rich molecule, sirtuin activity can also be promoted by supplementing with resveratrol and curcumin. Exercise and a decrease in caloric intake have also been shown to be effective ways to naturally increase the activity of sirtuins.

  12. What are telomeres?
    Telomeres are genome-protective caps that are located at the ends of chromosomes and indicate the age or suggested lifespan of a cell, in which the longer the telomere in length, the better. Telomeres are like the clear coating at the end of the shoelace string that keeps the lace from fraying; each time your cells divide, the chromosomal telomeres become shorter. Where maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the regulation of telomeres. Evidence shows that shorter telomeres contain lower NAD Just as NAD levels decrease with age, telomeres naturally shorten with age and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process.

  13. What is the goal of Prime NAD+?
    While all our Prime products are crafted to promote healthy aging at every level (including vision health, vascular strength, joint or hormone support), Prime NAD+ was specifically formulated to help you maintain a healthy reservoir of the youthful NAD molecule to help combat the cellular aging process.

  14. What foods contain NAD precursors or naturally assist in promoting NAD?
    Foods such as broccoli, cabbage, cucumber, avocado and tomato contain the NAD precursor NMN. Other foods containing higher levels of niacin and tryptophan, such as dairy, fish, beef, turkey and green vegetables, also help naturally increase NAD.

  15. How was NAD discovered?
    NAD was discovered over 100 years ago while scientists were doing experiments on fermentation in which yeast cells metabolize sugar and convert it into alcohol. Around twenty years later, scientists successfully separated the components of the yeast cells and discovered the chemical shape of the NAD molecule. In 1958, Jack Preiss and Phillip Handler showed how nicotonic acid is converted to NAD and identified responsible enzymes. The pathway that converts nicotonic acid to NAD is named the Preiss-Handler pathway.


Science


  • Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195 
  • Sharma, A., Chabloz, S., Lapides, R. A., Roider, E., & Ewald, C. Y. (2023). Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients, 15(2), 445. 
  • Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9 
  • Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x 
  • What is NAD+ and Why Is it Important? (n.d.). Elysium Health. https://www.elysiumhealth.com/blogs/aging101/what-is-nad-and-why-is-it-important 
  • Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077 
  • Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy 
  • Superfoodly, & Superfoodly. (2021). Pterostilbene supplement benefits: Longevity miracle or hoax. Superfoodlyhttps://superfoodly.com/pterostilbene-supplement-benefits-longevity-miracle-or-hoax/ 
  • ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins 
  • Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it 
  • Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD. Cell. 2007 May 4;129:473-84. 
  • Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74. 
  • Buonvicino D, Ranieri G, Pittelli M, Lapucci A, Bragliola S, Chiarugi A. SIRT1-dependent restoration of NAD+ homeostasis after increased extracellular NAD+ exposure. Journal of Biological Chemistry. 2021 Jul 1;297(1). 
  • Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018). 
  • de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021. 
  • Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17. 
  • Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916. 
  • Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018. 
  • Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357. 
  • Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485. 
  • Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316. 
  • Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87. 
  • Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78. 


Reviews


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by EMILYB

  • Shop Consultant
Fountain of Youth

Love this product! It gives me a consistent and steady energy throughout the day. It has also helped my complexion along with fine lines and wrinkles.

Response from Customer Service:

Thank you for the wonderful feedback! We're thrilled to hear that you're loving the product and experiencing consistent, steady energy throughout the day. It's also fantastic to know that it has positively impacted your complexion and helped with fine lines and wrinkles. Your satisfaction is incredibly important to us!

by PatriciaM

  • Shop Consultant
Just WOW

Seven months ago, I didn't think I could feel better than I did. At 62 years old, I was healthier and had more energy than I did at 30. Of course, exercise, good food choices and the products I take made a difference. I was already taking Magnesium and the powerhouse OPC-3 (the other components of the CORE3Health System), but the addition of NAD+ changed everything. Like others, my energy increased, but not of a stimulant nature. The energy was: 'I should be cleaning out a closet' energy. I also know I am looking younger, as the NAD+ seems to be erasing fine lines and wrinkles and improving the overall quality of my skin. The most significant improvement, however, has been in sleep. After struggling for 12 years, I struggle no more!!

Response from Customer Service:

Thank you for sharing your amazing journey with us! It's truly inspiring to hear how, at 62, you feel healthier and more energetic than ever. The combination of exercise, good food choices, and your commitment to products like Magnesium, OPC-3, and NAD+ clearly makes a significant difference. We're thrilled to hear about the boost in energy, the improvements in your skin, and most importantly, the better sleep you've achieved after 12 years of struggle. Your experience is a testament to the power of these products, and we appreciate your detailed and enthusiastic feedback. Just WOW indeed!

by TinaV

  • Shop Consultant
INCREDIBLE

Since taking this product I feel more energized and different! My skin is glowing and have received many compliments!

Response from Customer Service:

Thank you for sharing your incredible experience! We're thrilled to hear that you feel more energized and have noticed a positive difference since taking the product. It's fantastic that your skin is glowing and that you've received many compliments. Your positive feedback is greatly appreciated!

by PATTIL

  • Shop Consultant
NAD+

I've been using this product daily since it was introduced to us! I feel like I have more energy, especially when watching my 1 1/2 year old grandson! My facial complexion appears to be smoother; and the wrinkles are hardly visable! This is definitely a 'fountain of youth' product!

Response from Customer Service:

Thank you for your fantastic review! We're thrilled to hear that NAD+ has become a daily staple for you since its introduction. It's wonderful to know that you feel more energized, especially while spending time with your grandson, and that you've noticed improvements in your facial complexion and wrinkles. Your feedback and enthusiasm mean a lot to us. Thank you for sharing your experience and for considering NAD+ your 'fountain of youth' product!

by JackieS

  • Shop Consultant
Turn the clock backwards!

I have felt more energy and have noticed less wrinkles since on NAD+ (my son had told me that he noticed)
My skin is feeling youthful outside. I know I'm healthy inside from the science fighting at the cellular level.
I won't be without this supplement.

Response from Customer Service:

Thank you for sharing your fantastic experience with NAD+! We're thrilled to hear that you've felt more energetic and noticed fewer wrinkles. It's wonderful that your son has noticed the positive changes as well. Knowing that your skin feels youthful and that you're confident in the health benefits at the cellular level is truly inspiring. Your positive feedback means a lot to us. Thank you for being a valued customer and for sharing your story with us!