- Helps maintain healthy circulation by strengthening capillaries, arteries and veins
- Helps promote/support cardiovascular health
- Promotes/supports healthy nitric oxide levels
- Promotes/supports healthy blood vessel dilation/function
- Supports healthy platelet activity
- Helps maintain healthy cholesterol levels
- Demonstrates anti-inflammatory activity
- Helps support visual health/visual acuity
- Powerful free-radical scavenger
- Supports a healthy complexion
- Helps maintain normal blood glucose levels
- Supports healthy sperm quality
- Helps reduce mild menstrual cramping and abdominal pain
- Helps maintain joint flexibility
- Promotes sinus comfort
- Supports immune health
Why Choose OPC-3 Chews?
The formula for OPC-3 Chews includes some of the most powerful bioflavonoids currently known to research scientists. These bioflavonoids are scientifically termed oligomeric proanthocyanidins, commonly abbreviated OPCs. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. The best-researched OPCs are from grape seed, red wine, grape skin, bilberries, citrus fruit and Pycnogenol®†. The combination of these powerful OPCs is unique to OPC-3.*
OPC-3 Chews provide you with all the benefits of Isotonix OPC-3 ® in a delicious and convenient soft chew alternative, using natural flavors, colors and sweeteners. OPC-3 Chews are designed to deliver strong antioxidant defense, as well as a variety of other health benefits, including cardiovascular and immune support, maintenance of joint flexibility and much more.*
† Pycnogenol® is the registered trademark of Horphag Research, Ltd., and is protected by U.S. Patents #5,720,956, #6,372,266 and pending applications and international patents.
Pycnogenol is a plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled, natural environment is the unique source of this pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol's wide array of beneficial effects on the body, specifically in the realm of antioxidant health. Pine bark extract is a combination of proanthocyanidins, bioflavonoids, and organic acids. The extract has three basic properties, it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes normal production of endothelial nitric oxide, which promotes normal dilation of blood vessels.*
As one of the most powerful scavengers of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, help reduce mild menstrual cramping and abdominal pain, help maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, help maintain healthy cholesterol levels and support a healthy complexion.*
†Pycnogenol® is the registered trademark of Horphag Research, Ltd., and is protected by U.S. Patents #5,720,956, #6,372,266 and pending applications and international patents.
Grape Seed Extract 25 mg
Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract contains polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to maintain healthy cholesterol levels.*
Red Wine Extract 25 mg
Red wine extract is a potent antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.*
In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.*
Bilberry Extract 25 mg
Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry contain flavonoid pigments known as anthocyanin, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries, and veins. *
Citrus Bioflavonoids Extract 25 mg
Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect the plant's DNA and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health and help maintain healthy circulation by strengthening capillaries, arteries, and veins and demonstrate anti-inflammatory activity. The ability for citrus bioflavonoids to maintain healthy circulation by strengthening capillaries, arteries, and veins is also beneficial for helping maintain brain health and supports the production of neurotransmitters.*
What are OPCs?
OPC-3® Chews includes some of the most powerful bioflavonoids – biologically-active members of plant-derived compounds – currently known to research scientists. These bioflavonoids are scientifically termed oligomeric proanthocyanidins, commonly abbreviated OPCs. The purest and best-researched OPCs include grape seed, red wine, grape skin, bilberries, citrus fruit, and pine bark extract, or Pycnogenol®†.* This combination of powerful OPCs is unique to OPC-3. OPC-3 has been shown to provide a variety of health benefits, including but not limited to, combating free radicals, demonstrating anti-inflammatory activity, helping maintain healthy cholesterol levels, helping maintain healthy circulation by strengthening capillaries, arteries and veins, helping maintain joint flexibility, helping promote/support cardiovascular health, helping reduce mild menstrual cramping, helping support visual health/visual acuity, scavenging free radicals, promoting/supporting healthy blood vessel dilation, promoting/supporting healthy nitric oxide levels, supporting a healthy complexion, supporting healthy blood glucose levels, supporting healthy platelet activity and supporting healthy sperm quality.*
What is a free radical?
A free radical is a molecule with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, impacting cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, smoking, heavy exercising and aging all contribute to the creation of harmful free radicals. Free radicals can cause oxidative stress in the body. Normally the body is able to protect itself from free radicals, but if antioxidants are unavailable, or if free radical production becomes excessive, oxidation can occur.
What are antioxidants?
Antioxidants are cell protectors, neutralizing free radicals by donating an electron to the outermost shell of unbalanced molecules, rendering them harmless. Antioxidants are nutrients such as vitamins and minerals, and enzymes that are capable of counteracting the effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways: chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids found in OPCs play a key role in cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to demonstrate support for healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What sets OPC-3 Chews apart from other bioflavonoid products?
OPC-3 Chews offer scientifically supported OPCs, found to be the most powerful antioxidants for human health. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. This science-driven selection of OPCs is unique to OPC-3, which make OPC-3 Chews one of the most powerful free radical scavenging product available, in addition to our Isotonix OPC-3®.*
When will I notice the health benefits of taking OPC-3 Chews?
Many effects of OPC-3 start to work after a single serving, while studies with human volunteers have found that the health benefits of OPCs may take a while to occur. Taking OPC-3 daily enables the body to sustain a consistent antioxidant defense.*
Why should everyone take OPC-3?
Everyone is subject to the impact of free radicals and oxidative stress. Free radicals develop as byproducts of physiological processes that occur within the body. The impact may add up over the years. This process is largely responsible for the aging process.* OPCs are the most powerful natural free radical neutralizers, and you get the best of all OPCs by taking OPC-3 Chews. Regular use every day is vital for keeping free radicals in check for a long and healthy life. Laboratory studies have shown that OPCs are more powerful antioxidants than vitamin C and vitamin E.*
Are OPC-3 Chews safe?
Yes. OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout Europe. OPC-3 Chews are free of harmful chemicals, preservatives and alcohol.*
Are there any allergens in OPC-3 Chews?
OPC-3 Chews is a vegetarian product and contains no wheat, yeast, gluten, artificial flavor, starch, salt, preservatives or milk. OPC-3 Chews do contain soy.
What are the natural flavors in OPC-3 Chews?
The natural flavoring used in OPC-3 Chews is a blend of strawberry, cranberry, licorice, vanilla and rosemary.
What is the serving size for OPC-3 Chews?
Consume one (1) chew daily or as directed by your healthcare provider.
How do OPC-3 Chews compare to Isotonix OPC-3?
A single OPC-3 Chew contains 25 grams of Pycnogenol† – the same amount found in a single serving of our Isotonix OPC-3 product. OPC-3 Chews are a delicious and convenient way to also get your OPC-3 – perfect for travel or extra busy days.
† Pycnogenol® is the registered trademark of Horphag Research, Ltd., and is protected by U.S. Patents #5,720,956, #6,372,266 and pending applications and international patents.
- Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
- Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.
- Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
- Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.
- Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
- Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
- Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
- Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
- Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
- Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
- Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
- Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001.
- Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
- Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
- Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
- Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
- Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
- Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
- Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
- Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
- Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
- Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
- Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
- Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
- Rohdewald, P. Pycnogenol®. In “Flavonoids in Health and Disease”. Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
- Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
- Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
- Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
- Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002. Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
- Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
- Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
- Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
- Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
- Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
- Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
- Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
- Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
- Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
- Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
- Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
- Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
- Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
- Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000.
- Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.
- Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
- Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
- Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991.
- Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
- Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.
- Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.
- Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999.
- Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002.
- Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.
- Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
- Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
- Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.
- Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995.
- Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
- Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995.
- Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.
- Sobota AE. Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions. J Urology 131:1013-1016, 1984.
- Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.
- Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995.
- Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
- Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
- Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
- Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
- Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
- Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR. Pycnogenol® in the management of asthma. J Med Food 4: 201-209, 2001.
I had previously tried the powder version of OPC-3. I did not like the taste of the powder, so I could not find any reason to continue purchasing UNTIL someone recommended the OPC-3 Chews to me. They taste great, smell great AND they are much more convenient than the powder version. 10/10 would recommend to anyone who likes sweet, fruity gummies and wants something quick and convenient.
- Shop Consultant
Great way to take OPC-3 on the go or road. Convenient and easy. Outstanding
- Shop Consultant
Convenient and great flavor
There is no need to mix it with water, it's very convenient, and it tastes great!
- Shop Consultant
Great for travel or that extra dose
I don’t leave home without a few of these chews in my bag. If I need an extra dose or need the convenience of on-the-go, these are great.
I still feel the effects even in the chew form.
- Shop Consultant
Tasty little chews!
I love these chews, they help me keep the level of OPC's in my body throughout the day when I can't take my isotonix OPC-3. So I am able to pop 1-2 in my mouth during my busy day and still get good antioxidant protection for my body! So much easier than carrying little bottles of OPC powder around with me! Only problem with these is you can't eat just one! They may be sweet but they are actually good for you!