- Increases energy
- Provides strong antioxidant protection
- Helps improve mental focus
- Promotes cognitive health
- Promotes normal regulation of enzymes and hormones
- Helps with energy and stamina
- Contains no gluten, wheat, soy, yeast, artificial flavor, salt, preservatives or milk
- No Detectable GMOs
- Isotonic-Capable Drinkable Supplements
Why Choose Isotonix Essentials Turn Up?
Directions For Use
1. Pour contents of packet into a cup.
2. Add 8 fl. oz. of water into the cup and stir.
As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of water and powder are used.
How do I take Isotonix Essentials® Turn Up?
How often should I use Isotonix Essentials® Turn Up?
- Generate energy with ingredients like mangosteen and acai. Two scientifically supported ingredients because of their xanthione content. Xanthiones are similar in their ability to generate energy. Xanthones help support sustained energy, because they use fatty acids for energy, which have a longer energy burn than the sugars in many alternative energy products.
- Magnesium, Chromium and CoQ10 are some of the drivers of the body’s energy and recovery cycles.
- Support mental focus. Acai, especially when takin in combination with the other Turn Up ingredients, can support cognitive health.*
Potassium (Bicarbonate): 335 mg
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also supports a wide variety of biochemical and physiological processes. Among other things, potassium supports the normal transmission of nerve impulses, contraction of cardiac, skeletal and smooth muscle, synthesis of nucleic acids, maintenance of intracellular tonicity and maintenance of normal blood pressure.*
In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium supports normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat and supports the body’s ability to regulate water balance, recover from exercise and eliminate wastes.*
Açai Fruit Pulp: 200 mg/Açai Extract: 100 mg
The açai berry has been harvested from the depths of the rainforests of Brazil by the people who have been using it for thousands of years. Açai berries contain thiamin (B1), niacin (B2), riboflavin (B3), vitamin E, vitamin C, phosphorus, calcium, potassium, fiber, proteins and fatty acids such as Omega 6 and Omega 9.
Açai berries contain high levels of antioxidants, with studies showing higher antioxidant properties than red wine grapes. The dense pigmentation of açaí has led to several experimental studies of its anthocyanins, a group of polyphenols that give the deep color to fruits and vegetables and are high in antioxidant value.*
Magnesium (Citrate & Glycinate): 200 mg
Magnesium is a component of the mineralized part of bone and supports the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also promotes the normal mobilization of calcium, transporting it inside the cell for further utilization. It supports the normal functioning of muscle and nervous tissue. Magnesium promotes the normal synthesis of proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates.*
Magnesium is required for release of energy and it promotes the normal regulation of body temperature and proper nerve function, it helps the body handle stress, and it promotes a healthy metabolism. Magnesium works together with calcium to help maintain normal blood pressure. Importantly, magnesium also supports the body’s ability to build healthy bones and teeth, and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.*
L-Phenylalanine: 200 mg
L-Phenylalanine is an essential amino acid. Amino acids are the building blocks of protein. The body cannot produce L-phenylalanine so it must be obtained through diet or supplementation. The main dietary sources of L-phenylalanine are high protein foods such as meat, fish, eggs and dairy products. Sugar-free products containing the artificial sweetener aspartame (NutraSweet), which is composed of a combination of phenylalanine with another amino acid – aspartic acid, may also be a significant dietary source of L-Phenylalanine. Amino acids come in two forms, designated as L- and D- forms. The L- form is the naturally occurring form in foods, whereas the D- form is the synthetic variety.
L-phenylalanine acts as an amino acid precursor boosting noradrenalin production, which in turn increases mental alertness. L-phenylalanine helps to provide steady energy throughout the day, without the crash that typically follows the consumption of energy products with high sugar content.*
L-phenylalanine is an electrically-neutral amino acid, one of the 20 common amino acids used to biochemically form proteins and enzymes, coded by our DNA. L-phenylalanine is necessary for living organisms, including the human body. L-phenylalanine can be converted into L-tyrosine, another of the 20 protein-forming amino acids. L-tyrosine is converted into L-DOPA, which is further converted into dopamine, norepinephrine and epinephrine (latter three are known as the catecholamines).*
Vitamin B6, folic acid and vitamin C are needed in order to convert phenylalanine into noradrenaline. Noradrenalin is the brain’s natural energy source, promoting alertness, mental energy and focus.*
Guarana Extract: 160 mg
Guarana extract is derived from the seeds of the South American guarana shrub (Paullinia cupana), most of which originates in Brazil. Traditional uses of guarana by natives of the Amazon Rainforest include mixing crushed seeds in foods and beverages to promote alertness, mental energy and focus. As a dietary supplement, guarana is an effective energy booster, as it contains about twice the caffeine found in coffee beans (about three to four percent caffeine in guarana seeds compared to one to two percent for coffee beans). Guarana may enhance mental performance. The seeds of guarana are known to contain xanthines (caffeine) and have been widely used as a tonic in many South American countries, particularly Brazil. In studies, which have determined the total xanthine content of guarana powder, caffeine content typically averages 30 to 50 percent (depending on the extract). Related compounds such as theobromine and theophylline are found at levels of (one to three percent). Most of the scientific evidence on caffeine as a general stimulant and an aid to exercise performance shows convincingly that caffeine is effective.*
L-Taurine: 125 mg
L-Taurine is a building block for all the other amino acids. It aids in the transport of potassium, sodium, calcium and magnesium in and out of cells, thus supporting the normal generation of nerve impulses. It is a non-protein amino acid and is found in high amounts in the brain, retina, myocardium, skeletal and smooth muscle, platelets and neutrophils. It is plentiful in the fluids of muscle, lungs and nerve tissue. Dietary taurine mainly comes from animal food sources. Taurine is also present, in lower levels, in plant food sources like seaweed. It is classified as an essential amino acid and promotes normal micelle formation and fat absorption. Further, it promotes alertness, mental energy and focus. Taurine also has antioxidant. It may also help maintain a healthy cardiovascular system and support detoxifying activities.*
Mangosteen Powder: 100 mg
The mangosteen is an evergreen tree about 10 to 25 meters tall, grown in tropical climates such as Asia, South America and Polynesia. Mangosteen fruit is often called the “Queen of Fruits” due to its pleasant flavor. The mangosteen fruit is round with slightly flattened ends and is about six to seven centimeters in diameter. It has a smooth, thick, firm rind that is pale green when immature and dark purple or red-purple when ripe. Enclosed by the rind is the edible pulp in four to eight white segments. Each fruit has one to two seeds. The mangosteen fruit contains a compound called xanthones, which is thought to have antioxidant properties. The plant is also a rich source of other bioactive molecules including flavenoids, benzophenones, lactones and phenolic acids. A variety of xanthones can be isolated from the hull, rind, heartwood and flesh of mangosteen plants and fruit. Some studies have demonstrated that the xanthones found in mangosteen have antioxidant properties; six xanthones found in the mangosteen fruit were isolated from the fruit peel.*
L-Tyrosine: 100 mg
L-Tyrosine is an amino acid found naturally in our bodies. Tyrosine is metabolized into neurotransmitters such as dopamine, norepinephrine and epinephrine. Neurotransmitters are important because they carry messages from one nerve cell to another, thereby playing a vital role in our muscular and cognitive function. Scientists believe that the main cause of mental fatigue is directly related to decreased levels of dopamine, norepinephrine and other neurotransmitters in the brain. Many scientists believe that tyrosine can help relieve occasional symptoms of mental and physical fatigue.*
L-Glycine: 100 mg
Glycine is an important amino acid that supports the body’s synthesis of non-essential amino acids. Glycine is one of the few amino acids that can spare glucose for energy by improving glycogen storage. Glycine is useful in the synthesis of DNA and is readily converted into creatine. The body requires glycine for the maintenance of the central nervous system. In men, glycine plays an essential role in maintaining healthy prostate functions.*
Vitamin C: 100 mg
Vitamin C, a water-soluble vitamin that acts as an antioxidant, has been proven to support the normal growth and repair of body tissues, support of cardiovascular health, reduced oxidative stress, and promote cognitive health and performance.*
Coenzyme Q10: 60 mg
Coenzyme Q10 belongs to a family of substances called ubiquinones, and is a fat-soluble, wax-like substance that is part of the respiratory chain. It is synthesized in the cells and is involved in electron transport and energy production in mitochondria where about 95 percent of the total energy required by the human body is generated. In the cellular system, CoQ10 supports the generation of energy from oxygen, in the form of ATP. CoQ10 also exhibits activity as a free radical scavenger and an antioxidant. The antioxidant activity in the mitochondria and cell membranes protects against peroxidation of lipid membranes.*
Coenzyme Q10 can be found in spinach, broccoli, nuts, meats and fish. In the body, it is found in highest concentration in the cells of the heart, liver, kidney, spleen and pancreas, which all require vast amounts of energy. Supplementation with CoQ10 may be most beneficial for adults because the levels of CoQ10 in the body tend to peak around the age of twenty and then decline with age.*
Pomegranate Extract (40% Ellagiac Acid): 50 mg
One pomegranate delivers 40 percent of an adult's daily vitamin C requirement, and also provides folic acid and antioxidants. Pomegranates are high in polyphenols. The most abundant polyphenols in pomegranate are hydrolysable tannins, particularly punicalagins, which research has shown to be the antioxidant responsible for the free-radical scavenging ability of pomegranate juice.*
Many food and dietary supplement makers have found the advantages of using pomegranate extracts (which have no sugar, calories or additives), instead of the juice, as ingredients in their products. Many pomegranate extracts are essentially ellagic acid, which is largely a by-product of the juice extraction process. Ellagic acid has been shown in published studies to absorb into the body when consumed as ellagitannins such as punicalagins.*
Yerba Maté Extract: 45 mg
Yerba maté is an evergreen with white flowers and red fruit, found naturally only in South America. The dried or roasted leaves, which contain caffeine, are used in nutritional products. Yerba maté contains xanthines, which are alkaloids in the same family as caffeine, theophylline and theobromine, well-known stimulants also found in coffee and chocolate. Yerba Maté also contains potassium, magnesium and manganese.*
Like coffee, Yerba Maté stimulates the central nervous system. It may promote strong heart contractions, heart rhythm, and may support the break down of sugars in the body. It is largely used to fight occasional fatigue. Yerba Maté has been shown to promote alertness, mental energy and focus, without the negative effects typically created by similar compounds. Yerba Maté creates a powerful answer to occasional mental and physical fatigue. Yerba maté is used worldwide as a rejuvenator of energy and mental alertness.*
Green Tea: 25 mg
Green tea extract has been used nutritionally for centuries in India and China. A number of beneficial health effects are related to regular consumption of green tea and dried/powdered extracts of green tea that are available in some dietary supplements. Green tea is prepared by picking, lightly steaming and allowing the leaves to dry. The active components in green tea are a family of polyphenols (catechins) and flavonols, which possess potent antioxidant activity. Several catechins are present in major quantities; epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG). EGCG makes up around 10 to 50 percent of the total catechin content and appears to be the most powerful of all the catechins, with demonstrated antioxidant activity. Green tea extract is reported to have positive effects including cardiovascular system support.*
Green tea contains a substantial amount of antioxidants, including epigallocatechin gallate (EGCG). Green tea’s polyphenolic antioxidants support cardiovascular health, help combat free radicals and support the normal oxidation of LDL cholesterol. Aside from the clear benefits of green tea as an antioxidant, recent studies have suggested green tea may support weight control.* ‡This extract is decaffeinated.
L-Carnitine: 20 mg
L-carnitine is an amino acid that is found in nearly all cells of the body. L-carnitine supports fat metabolism in the heart, organs and tissue. L-carnitine occurs naturally in animal products and only very small amounts are found in plants, with a few exceptions, such as avocado and some fermented soy products. It also plays an essential role in the transportation of long chain fatty acids into the mitochondria of the cell, which results in additional energy in the form of adenosine triphosphate (ATP). L-carnitine is synthesized in the body, mainly in the liver and kidneys, from the essential amino acids L-lysine and L-methionine.*
Niacinamide: 15 mg NE
Niacin is a water-soluble vitamin that supports many aspects of health, growth and reproduction. Niacin supports the proper functioning of the digestive system, skin and nerves. It promotes the conversion of food to energy. Niacin is found in dairy products, poultry, fish, lean meats, nuts, eggs, legumes, and enriched breads and cereals.*.
Lipase: 5 mg
Lipase is a fat-digesting enzyme that supports the body’s normal break down of dietary fats into an absorbable form. Lipases, such as human pancreatic lipase, support the normal conversion of triglyceride substrates found in oils from food to monoglycerides and free fatty acids. Some lipases also work within the interior spaces of living cells to support the normal degradation of lipids.*
Vitamin B6 (Pyridoxine HCl): 4.1 mg
Poultry, fish, whole grains and bananas are the main dietary sources of vitamin B6. B6 supports normal protein and amino acid metabolism, and helps maintain proper fluid balance. It also assists in the maintenance of healthy red and white blood cells, which supports our overall health. Vitamin B6 promotes normal hemoglobin synthesis (hemoglobin is the protein portion of red blood cells which carries oxygen throughout the body). Because vitamin B6 is involved in the synthesis of neurotransmitters in the brain and nerve cells, it has been recommended as a nutrient to support mental function, specifically mood. Athletic supplements often include vitamin B6 because it promotes the conversion of glycogen to glucose for energy in muscle tissue. Vitamin B6, when taken with folic acid, has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal cardiovascular health. Vitamin B6 should be taken as a part of a complex of other B vitamins for best results.*
Pantothenic Acid (d-Calcium Pantothenate): 4 mg
Pantothenic acid promotes proper neurotransmitter activity in the brain. Pantothenic acid is also known as the anti-stress vitamin and it promotes the secretion of hormones essential for optimal health.*
Boron: 2 mg
Boron is a mineral found at high levels in plant foods such as dried fruits, nuts, dark green, leafy vegetables, applesauce, grape juice and cooked dried beans and peas. Boron is found in most tissues, but mainly in the bone, spleen and thyroid. Boron supports normal bone and hormone metabolism. Boron supports the body’s ability to build and maintain healthy bones. It also helps the body retain calcium and magnesium to promote proper bone mineralization. Boron is an essential cofactor for the conversion of vitamin D to its active form. It supports the maintenance of healthy cell membranes, proper mental functioning and alertness, and helps maintain normal serum estrogen levels and ionized calcium.*
Zinc (Gluconate): 1.3 mg
Zinc is largely found in fortified cereals, red meats, eggs, poultry and certain seafood, including oysters. Zinc is a component of multiple enzymes and proteins. It is also involved in the regulation of gene expression. Zinc is an essential trace mineral that has functions in 300 different enzymatic reactions. Thus, zinc plays a part in almost all biochemical pathways and physiological processes. More than 90 percent of the body’s zinc is stored in the bones (30 percent) and muscles (60 percent), but zinc is also found in virtually all body tissues. Zinc is involved in such a great number of enzymatic processes it has been found to positively affect a large range of physiological functions such as energy production, cognitive function and carbohydrate metabolism. Zinc is an essential amino acid that is involved in many enzymatic reactions in the body, ranging from the synthesis of proteins and collagen, to the production of cellular energy.*
Chromium (Arginate, Picolinate): 215 mcg
Chromium arginate is a form of chromium that is bonded with the essential amino acid Arginine. Like chromium picolinate, it too can support normal insulin activity and the metabolism of protein, fat and carbohydrates.* Together with chromium picolinate, chromium arginate helps to support cardiovascular health by helping to maintain normal insulin sensitivity. It also helps maintain healthy blood sugar and cholesterol levels.*
Copper (Gluconate): 166 mcg
The richest sources of dietary copper derive from organ meats, seafood, nuts, seeds, wheat bran cereal, whole grain products and cocoa products. Copper has antioxidant properties and acts as a component of enzymes in iron metabolism. It is an essential trace mineral. Copper supports normal infant development, red and white blood cell maturation, iron transport, bone strength, cholesterol metabolism, myocardial contractility, glucose metabolism, brain health and immune function.*
Folic Acid: 30 mcg
Folic acid is mainly found in fruits and vegetables. Dark, leafy greens, oranges, orange juice, beans, peas and Brewer’s yeast are the best sources. Folic acid plays a key role by boosting the benefits of B12 supplementation. These two B vitamins join forces and work together to help maintain normal red blood cells. Folic acid assists in the normal utilization of amino acids and proteins, as well as supporting the construction of the material for DNA and RNA synthesis, which is necessary for all bodily functions. Scientific studies have found that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels. This works toward supporting a healthy cardiovascular and nervous system.*
Vitamin B12 (Cyanocobalamin): 3.6 mcg
Vitamin B12 is a bacterial product naturally found in animal products, especially organ meats, such as liver, with small amounts derived from peanuts and fermented soy products, such as miso and tempeh. It is essential that vegetarians consume a vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored in the liver and other tissues for later use. It supports the normal maintenance of cells, especially those of the nervous system, bone marrow and intestinal tract. Vitamin B12 supports normal homocysteine metabolism (homocysteine is an amino acid that is formed within the body). Normal homocysteine levels are important for maintaining cardiovascular health. Folate and B12, in their active coenzyme forms, are both necessary to support the conversion of homocysteine to methionine, thus helping to maintain healthy blood levels of homocysteine.*
- Adhami, V., et al. Molecular targets for Green Tea in prostate cancer prevention. Journal of Nutrition. 133(7):2417S-2424S, 2003.
- Altura BM and Altura BT. Magnesium and cardiovascular biology: An important link between cardiovascular risk factors and atherogenesis. Cell Mol Biol Res. 41:347-59, 1995.
- Anderson RA, Bryden NA, Polansky MM. Lack of toxicity of chromium chloride and chromium picolinate in rats. J Amer Coll Nutr. 1997; 16:273-279.
- Anderson RA. Chromium, glucose intolerance and diabetes. J Amer Coll Nutr. 1998; 17:548-555.
- Anderson RA. Effects of chromium on body composition and weight loss. Nutr Rev. 1998; 56:266-270.
- Appel LJ. Nonpharmacologic therapies that reduce blood pressure: A fresh perspective. Clin Cardiol. 22:1111-5, 1999.
- Ascherio, A., et al. Intake of Potassium, Magnesium, Calcium, and Fiber and Risk of Stroke among US Men. Circulation. 98: 1198 – 1204, 1998.
- Aviram, M., et al. Pomegranate Juice Consumption for 3 Years by Patients with Carotid Artery Stenosis Reduces Common Carotid Intima-media Thickness, Blood Pressure, and LDL Oxidation. Clinical Nutrition. 23: 423-433, 2004.
- Aviram, M., et al. Pomegranate Juice Consumption Reduces Oxidative Stress, Atherogenic Modifications to LDL, and Platelet Aggregation: Studies in Humans and in Atherosclerotic Apolipoprotein E-deficient Mice. American Journal of Clinical Nutrition. 71(5): 1062-1076, 2000.
- Barker J. Insomnia options; natural medicine choices. Townsend Letter for Doctors and Patients. April 2004.
- Berube-Parent, S., et al. Effects of Encapsulated Green Tea and Guarana Extracts Containing a Mixture of Epigallocatechin-3-gallate and Caffeine on 24-H Energy Expenditure and Fat Oxidation in Men. British Journal of Nutrition. 94(3): 432-436, 2005.
- Bettuzzi, S., et al. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-grade Prostate Intraepithelial Neoplasia: a Preliminary Report from a One-year Proof-of-Principle Study. Cancer Research. 66(2): 1234-1240, 2006.
- Bilbey, D.L. J., et al. Muscle cramps and magnesium deficiency: case reports. Can Fam Physician. 42:1348-51, 1996.
- Bohmer T, Rynding A, Solberg HE. Carnitine levels in human serum in health and disease. Clin Chim Acta. 1974; 57:55-61.
- Boozer, C., et al. An Herbal Supplement Containing Ma Huang-Guarana for Weight Loss: a Randomized, Double-blind Trial. International Journal of Obesity. 25(3): 316-324, 2001.
- Brevetti G, Chiarello M, Ferulano G, et al. Increases in walking distance in patients with peripheral vascular disease: a double-blind, cross-over study. Circul. 1988; 77:767-773.
- Brilla, L. R., et al. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 11(3):326-329, 1992.
- Brown R. and Gerbarg P. Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. J Psychiatr Pract. 7(2):75-91, 2001.
- Bryan, J., et al. Short-Term Folate, Vitamin B-12 or Vitamin B-6 Supplementation Slightly Affects Memory Performance But Not Mood in Women of Various Ages. Journal of Nutrition. 132: 1345-1356, 2002.
- Caddell JL. Magnesium deficiency promotes muscle weakness, contributing to the risk of sudden infant death (SIDS) in infants sleeping prone. Magnes Res. 14(1-2):39-50, 2001. Review.
- Cao, H., et al. Green Tea Increases Anti-inflammatory Tristetraprolin and Decreases Pro-inflammatory Tumor Necrosis Factor mRNA Levels in Rats. Journal of Inflammation. 4:1, 2007.
- Carr, A., et al. Vitamin C Protects Against and Reverses Specific Hypochlorous Acid- and Chloramine-dependent Modifications of Low-density Lipoprotein. Biochemical Journal. 346: 491–499, 2000.
- Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother. 1998; 32:428-431.
- Chairungsrilerd, N., et al. Effect of Gamma-mangostin through the Inhibition of 5-Hydroxy-tryptamine2A Receptors in 5-Fluoro-alpha-methyltryptamine-induced Head Twitch Responses of Mice. British Journal of Pharmacology. 123(5): 855-862, 1998.
- Chollet D et al. Blood and brain magnesium in inbred mice and their correlation with sleep quality. Am J Physiol Regul Integr Comp Physiol. 279(6):R2173-8, 2000.
- Corsonello A et al. Serum magnesium levels and cognitive impairment in hospitalized hypertensive patients. Magnes Res. 14(4):273-82, 2001.
- Crane FL, Sun IL, Sun EE. The essential functions of coenzyme Q. Clin Investig. 1993; 71(Suppl):S55-S59.
- Dahle, L. O., et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 173(1):175-180, 1995.
- De Nigris, F., et al. Beneficial Effects of Pomegranate Juice on Oxidation-Sensitive Genes and Endothelial Nitric Oxide Synthase Activity at Sites of Perturbed Shear Stress. Proceedings of the National Academy of Sciences. 102(13): 4896-4901, 2005.
- Del Pozo-Insfran, D., et al. Açai (Euterpe oleracea Mart.) Polyphenolics in Their Glycoside and Aglycone Forms Induce Apoptosis of HL-60 Leukemia Cells. Journal of Agricultural and Food Chemistry. 54(4):1222-1229, 2006.
- Del Pozo-Insfran, D., et al. Phytochemical Composition and Pigmentation S
- Demirkaya S et al. A comparative study of magnesium, flunarizine and amitriptyline in the prophylaxis of migraine. J Headache Pain. 1:179-86, 2000.
- Doshi, S., et al. Folic Acid Improves Endothelial Function in Coronary Artery Disease via Mechanisms Largely Independent of Homocysteine Lowering. Circulation. 105(1): 22-26, 2002.
- Duthie, S., et al. Homocysteine, B vitamin Status, and Cognitive Function in the Elderly. American Journal of Clinical Nutrition. 75(5):908-913, 2002.
- Elisaf M, Milionis H, Siamopoulos K. Hypomagnesemic hypokalemia and hypocalcemia: Clinical and laboratory characteristics. Mineral Electrolyte Metab. 23:105-12, 1997.
- Ellis, G., et al. Neutrophil Superoxide Anion–generating Capacity, Endothelial Function and Oxidative Stress in Chronic Heart Failure: Effects of Short- and Long-term Vitamin C Therapy. Journal of the American College of Cardiology. 36: 1474 – 1482, 2000.
- Ellis, J., et al. Response of Vitamin B-6 Deficiency and the Carpal Tunnel Syndrome to Pyridoxine. Proceedings of the National Academy of Sciences. 79: 7494-7498, 1982.
- Engelhart, M. Dietary Intake of Antioxidants and Risk of Alzheimer Disease. Journal of the American Medical Association. 287:3223-3229, 2002.
- Folkers K, Mortensen SA, Littarru GP, Yamagami T, Lenaz G, eds. The biochemical and clinical aspects of coenzyme Q. Clin Investig. 1993; 71(Suppl):S51-S178.
- Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the protective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci USA. 1985; 82:901-904.
- Friso, S., et al. Low Plasma Vitamin B-6 Concentrations and Modulation of Coronary Artery Disease Risk. American Journal of Clinical Nutrition. 79(6): 992-998, 2004.
- Gruber H et al. Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton. BMC Musculoskelet Disord. 4(1):7, 2003.
- Guran T et al. Cognitive and psychosocial development in children with familial hypomagnesaemia. Magnes Res. 24(1):7-12, 2011.
- Harada, N., et al. Taurine Alters Respiratory Gas Exchange and Nutrient Metabolism in Type 2 Diabetic Rats. Obesity Research. 12: 1077-1084, 2004.
- Hassimotto, N., et al. Antioxidant Activity of Dietary Fruits, Vegetables, and Commercial Frozen Fruit Pulps. Journal of Agricultural and Food Chemistry. 53: 2928-2935, 2005.
- Hillstrom, R., et al. Vitamin C Inhibits Lipid Oxidation in Human HDL. Journal of Nutrition. 133: 3047-3051, 2003.
- Ho, C., et al. Garcinone E, a Xanthone Derivative, Has Potent Cytotoxic Effect against Hepatocellular Carcinoma Cell Lines. Planta Medica. 68(11): 975-979, 2002.
- Hornig, B., et al. Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure. Circulation. 97: 363 – 368, 1998.
- Hornyak M et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 21:501-5, 1998.
- Houston M. The role of magnesium in hypertension and cardiovascular disease. J Clin Hypertens (Greenwich). 13(11):843-7, 2011. Review.
- Huang, R., et al. N-Acetylcysteine, Vitamin C and Vitamin E Diminish Homocysteine Thiolactone-Induced Apoptosis in Human Promyeloid HL-60 Cells. Journal of Nutrition. 132: 2151-2156, 2002.
- Huang, T., et al. Pomegranate Flower Improves Cardiac Lipid Metabolism in a Diabetic Rat Model: Role of Lowering Circulating Lipids. British Journal of Pharmacology. 145: 767-774, 2005.
- Huerta MG, Roemmich JN, Kington ML, et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care. 28:1175-81, 2005.
- Huskisson E et al. The influence of micronutrients on cognitive function and performance. J Int Med Res. 35(1):1-19, 2007. Review.
- Inna Slutsky et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 65(2):165-77, 2010.
- Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
- International Symposium on the Health Effects of Dietary Chromium. J Trace Elem Exp Med. 1999; 12:53-169.
- Iso, H., et al. The Relationship between Green Tea and Total Caffeine Intake and Risk for Self-reported Type 2 Diabetes among Japanese Adults. Annals of Internal Medicine. 144(8): 554-562, 2006.
- Jee SH et al. The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials. Am J Hypertens. 15:691-6, 2002.
- Jung, H., et al. Antioxidant Xanthones from the Pericarp of Garcinia Mangostana (Mangosteen). Journal of Agricultural and Food Chemistry. 54(6): 2077-2082, 2006.
- Kaats GR, Blum K, Fisher JA, Adelman JA. Effects of chromium picolinate supplementation on body composition: a randomized, double-masked, placebo-controlled study. Curr Therap Res. 1996; 57:747-756.
- Kang, S., et al. Oxygen Tension Regulates the S
- Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol. 10:525-35, 1990.
- Kovacs, E. and Mela, D. Metabolically Active Functional Food Ingredients for Weight Control. Obesity Reviews. 7(1): 59-78, 2006.
- Lenton, Kevin J., et al. Vitamin C Augments Lymphocyte Glutathione in Subjects with Ascorbate Deficiency. American Journal of Clinical Nutrition. 77: 189-195, 2003
- Li, C., et al. Green Tea Polyphenols Modulate Insulin Secretion by Inhibiting Glutamate Dehydrogenase. The Journal of Biological Chemistry. 281(15):10214-21, 2006.
- Lopez-Ridaura R et al. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care. 27:134-40, 2004.
- Lukaski, H. Low Dietary Zinc Decreases Erythrocyte Carbonic Anhydrase Activities and Impairs Cardiorespiratory Function in Men During Exercise. American Journal of Clinical Nutrition. 81: 1045 – 1051, 2005.
- Maizels, M., et al. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache. 44(9):885-90, 2004.
- Malik, A., et al. Pomegranate Fruit Juice for Chemoprevention and Chemotherapy of Prostate Cancer. Proceedings of the National Academy of Sciences. 102(41): 14813-14818, 2005.
- Marx, F., et al. The Total Oxidant Scavenging Capacity (TOSC) Assay and Its Application to European and Under-utilized Brazilian Fruits. Lebensmittelwissenschaftliches Seminar der DAAD-Alumni, Fortaleza/Brasilien. 11: 21-23, 2005
- Mauskop, A., et al. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 5(1):24-27, 1998.
- Merz W. Chromium in human nutrition: a review. J Nutr. 1993; 123:626-633.
- Meyer KA et al. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr. 71:921-30, 2000.
- Murase, T., et al. Green Tea Extract Improves Endurance Capacity and Increases Muscle Lipid Oxidation in Mice. American Journal of Physiology. 288(3): R708-715, 2005.
- Nakatani, K., et al. Inhibitions of Cyclooxygenase and Prostaglandin E2 Synthesis by -Mangostin, a Xanthone Derivative in Mangosteen, in C6 Rat Glioma Cells. Biochemical Pharmacology. 63: 73-79, 2002.
- Nakatani, K., et al. -Mangostin Inhibits Inhibitor- B Kinase Activity and Decreases Lipopolysaccharide-Induced Cyclooxygenase-2 Gene Expression in C6 Rat Glioma Cells. Molecular Pharmocology. 66: 667-674, 2004.
- Nam, S., et al. Ester Bond-containing Tea Polyphenols Potently Inhibit Proteasome Activity In Vitro and In Vivo. Journal of Biological Chemistry. 276(16): 13322-13330, 2001.
- Neurath, A., et al. Punica Granatum (Pomegranate) Juice Provides an HIV-1 Entry Inand Candidate Topical Microbicide. BioMed Central Infectious Diseases. 4(41): 1-12, 2004.
- New SA et al. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 65:1831-9, 1997.
- O’Shea, E. and Lin, K. The Therapeutic Effect of Amino Acids in Prostate Cancer Patients. American Institute for Cancer Research Nutrition and Cancer Prevention. 1-24, 2005.
- Paddon-Jones, D., et al. Exogenous Amino Acids Stimulate Human Muscle Anabolism without Interfering with the Response to Mixed Meal ingestion. American Journal of Physiology, Endocrinology, and Metabolism. 288(4): E761-E767, 2005.
- Paleologos M, et al. Cohort Study of Vitamin C Intake and Cognitive Impairment. American Journal of Epidemiology. 148(1):45-50, 1998.
- Paolisso G et al. Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr. 55:1161-7, 1992.
- Parcell, S. Sulfur in Human Nutrition and Application in Medicine. Alternative Medicine Review. 7(1): 22-44, 2002.
- Peacock JM et al. Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study. Annals of Epidemiology. 9:159-65, 1999.
- Peikert, A., et al. Prophylaxis of migraine with oral magnesium: Results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia. 16(4):257-63, 1996.
- Perumal, S., et al. Energy-modulating Vitamins—a New Combinatorial Therapy Prevents Cancer Cachexia in Rat Mammary Carcinoma. British Journal of Medicine. 93(6): 901-909, 2005.
- Peterman, R. and Goodhart, R. Current Status of Vitamin Therapy in Nervous and Mental Disease. The American Journal of Clinical Nutrition. 2(1): 11-21, 1954.
- Popoviciu L et al. Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency (abstract). Rom J Neurol Psychiatry. 31:55-61, 1993.
- Preuss HG, Gondal JA, Lieberman S. Association of macronutrients and energy intake with hypertension. J Am Coll Nutr. 15:21-35, 1996.
- Prockup LD, Engel WK, Shug AL. Nearly fatal muscle carnitine deficiency with full recovery after replacement therapy. Neurol. 1983; 33:1629-1631.
- Quadri, P., et al. Homocysteine, Folate, and Vitamin B-12 in Mild Cognitive Impairment, Alzheimer Disease, and Vascular Dementia. American Journal of Clinical Nutrition. 80(1): 114-122, 2004.
- Ravikumar, A., et al. Tryptophan and Tyrosine Catabolic Pattern in Neuropsychiatric Disorders. Neurology India. 48(3): 231-238, 2000.
- Ravindranath, M., et al. Epicatechins Purified from Green Tea (Camellia Sinensis) Differentially Suppress Growth of Gender-Dependent Human Cancer Cell Lines. Evidence Based Complementary and Alternative Medicine. 3(2): 237-247, 2006.
- Rebouche CJ, Paulson DJ. Carnitine metabolism and function in humans. Ann Rev Nutr. 1986; 6:41-68.
- Rebouche CJ. Carnitine function and requirements during the life cycle. FASEB J. 1992; 6:3379-3386.
- Riggs, K., et al. Relations of Vitamin B-12, Vitamin B-6, Folate, and Homocysteine to Cognitive Performance in the Normative Aging Study. American Journal of Clinical Nutrition. 63(3):306-314, 1996.
- Rink, L. and Kirchner, H. Zinc-Altered Immune Function and Cytokine Production. Journal of Nutrition. 130: 1407S-1411S, 2000.
- Roberts, A., et al. The Effect of an Herbal Supplement Containing Black Tea and Caffeine on Metabolic Parameters in Humans. Alternative Medical Review. 10(4): 321-325, 2005.
- Rodriguez-Moran M and Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects. Diabetes Care. 26:1147-52, 2003.
- Rodriques, R., et al. Total Oxidant Scavenging Capacities of Euterpe Oleracea Mart. (Açaí Seeds) and Their Polyphenolic Compounds. Annual Meeting of the Brazilian Society of Chemistry. 29: 19-22, 2006.
- Roffe, C., et al. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 8(5):CR326-CR330, 2002.
- Rude KR. Magnesium metabolism and deficiency. Endocrinol Metab Clin North Am. 22:377-95, 1993.
- Rude R et al. Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem. 15(12):710-716, 2004.
- Ruz, M., et al. Single and Multiple Selenium-Zinc-Iodine Deficiencies Affect Rat Thyroid Metabolism and Ultrastructure. Journal of Nutrition. 129: 174-180, 1999.
- Ryder K et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 53(11):1875-1880, 2005.
- Sales CH et al. Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. Clin Nutr. 30(3):359-64, 2011.
- Salonen, R., et al. Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation. 107: 947 – 953, 2003.
- Sanjuliani AF et al. Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients. Int J Cardiol. 56:177-83, 1996.
- Santillo, V. and Lowe, F. Role of Vitamins, Minerals and Supplements in the Prevention and Management of Prostate Cancer. International Brazilian Journal of Urology. 32(1): 3-14, 2000.
- Saris NE, Mervaala E, et al. Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Sato, A., et al. α-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells. Journal of Pharmacology. 95: 33-40, 2004.
- Sato-Mito N et al. The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. Sleep Med. 12(3):289-94, 2011.
- Schauss, A., et al. Antioxidant Capacity and Other Bioactivities of the Freeze-dried Amazonian Palm Berry, Euterpe Oleraceae Mart. (Acai). Journal of Agricultural and Food Chemistry. 54(22): 8604-10, 2006.
- Senthilkumar, R., et al. Glycine Modulates Hepatic Lipid Accumulation in Alcohol-induced Liver Injury. Polish Academy of Sciences. 55: 603-611, 2003.
- Shaneyfelt, M., et al. Natural Products that Reduce Rotavirus Infectivity Identified by a Cell-based Moderate-throughput Screening Assay. Virology Journal. 3:68, 2006.
- Shechter M et al. Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease. Am J Cardiol. 91:517-21, 2003.
- Shechter M et al. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation.102:2353-58, 2000.
- Simon, J., et al. Relation of Serum Ascorbic Acid to Mortality among US Adults. Journal of the American College of Nutrition. 20: 255-263, 2001.
- Sinclair, S., et al. Migraine headaches: nutritional, botanical and other alternative approaches. Alternative Medicine Review. 4(2):86-95, 1999.
- Solzbach, U., et al. Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients. Circulation. 96: 1513 – 1519, 1997.
- Song Y et al. Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care. 27:59-65, 2004.
- Speetjens JK, Collins RA, Vincent JB, Woski SA. The nutritional supplement chromium (III) tris (picolinate) cleaves DNA. Chem Res Toxicol. 1999; 12:483-487.
- Stendig-Lindberg G et al. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res. 6:155-63, 1993.
- Suksamrarn, S., et al. Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia Mangostana. Chemical & Pharmaceutical Bulletin. 51(7):857-859, 2003.
- Svetkey LP et al. Effects of dietary patterns on blood pressure: Subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Arch Intern Med. 159:285-93, 1999.
- Szyndler, J., et al. Effect of Kindled Seizures on Rat Behavior in Water Morris Maze Test and Amino Acid Concentrations in Brain Structures. Pharmacological Reports. 58: 75-82, 2006.
- Tanabe, K., et al. Efficacy of oral magnesium administration on decreased exercise tolerance in a state of chronic sleep deprivation. Jpn Circ J. 62(5):341-346, 1998.
- Tanabe, K., et al. Erythrocyte magnesium and prostaglandin dynamics in chronic sleep deprivation. Clin Cardiol. 20(3):265-268, 1997.
- Tang, X. and Shay, N. Zinc Has an Insulin-Like Effect on Glucose Transport Mediated by Phosphoinositol-3-Kinase and Akt in 3T3-L1 Fibroblasts and Adipocytes. Journal of Nutrition. 131: 1414-1420. 2001.
- Title, L., et al. Effect of Folic Acid and Antioxidant Vitamins on Endothelial Dysfunction in Patients with Coronary Artery Disease. Journal of the American College of Cardiology. 36: 758-765, 2000.
- Tranquilli AL et al. Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol. 8:55-8, 1994.
- Trauninger, A., et al. Oral magnesium load test in patients with migraine. Headache. 42(4):114-119, 2002.
- Tsuboyama-Kasaoka, N., et al. Taurine (2-aminoethanesulfonic acid) Deficiency Creates a Vicious Circle Promoting Obesity. Endocrinology. 147(7): 3276-3284, 2006.
- Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 69(4):727-36, 1999.
- Ukkola, O., et al. Protein Tyrosine Phosphatase 1B Variant Associated with Fat Distribution and Insulin Metabolism. Obesity Research. 13: 829-834, 2005.
- Voravuthikunchai, S. and Kitpipit, L. Activity of Medicinal Plant Extracts against Hospital Isolates of Methicillin-resistant Staphylococcus Aureus. Clinical Microbiology and Infection. 11(6): 510-512, 2005.
- Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 24:27-37, 2003.
- Wang, F., et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache. 43(6):601-610, 2003.
- Warburton, D., et al. An Evaluation of a Caffeinated Taurine Drink on Mood, Memory and Information Processing in Healthy Volunteers without Caffeine Abstinence. Psychopharmacology. 158: 322-328, 2001.
- Werbach, M. Nutritional Strategies for Treating Chronic Fatigue Syndrome. Alternative Medicine Review. 5(2):93-108, 2000.
- Wester PO. Magnesium. Am J Clin Nutr. 45:1305-12, 1987.
- Westerterp- Plantenga, M., et al. Body Weight Loss and Weight Maintenance in Relation to Habitual Caffeine Intake and Green Tea Supplementation. Obesity Research. 13: 1195- 1204, 2005.
- Widman L et al. The dose-dependent reduction in blood pressure through administration of magnesium. A double blind placebo controlled cross-over study. Am J Hypertens. 6:41-5, 1993.
- Won, S., et al. Catechins Inhibit Angiotensin II-induced Vascular Smooth Muscle Cell Proliferation via Mitogen-activated Protein Kinase Pathway. Experimental and Molecular Medicine. 38(5): 525-534, 2006.
- Woolhouse, M. Migraine and tension headache--a complementary and alternative medicine approach. Aust Fam Physician. 34(8):647-51, 2005. Review.
- Yu-Yahiro, J. A. Electrolytes and their relationship to normal and abnormal muscle function. Orthop Nurs. 13(5):38-40, 1994.
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Great for High School & College kids
This product is the best for my college kids! They stay consistent because of the ease of taking it, great taste and the energy/focus that it gives them. I know they are getting great supplements every day which helps them to stay healthy.
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I'm a person who gets the jitters from one cup of coffee, so I am thrilled to be able to take this product!! I can be drowsy and tired, and 15 minutes after I drink it, the only thing I feel is my normal not tired self.....No racing heart, no jitters...just awake and focused!
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November 15, 2019
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Turn Up review
Turn up is great! I use it as a pre-workout. Gives me sustained energy with no jitters. Expected nothing less from a Market America product
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We love Turn Up! Its an easy product to take it taste great, I love how I feel after I take it I get nice energy and clear thinking with no rush just nice gentle feel better energy. Everyone who I share it with wants more.... I was told today it "Happy Juice" :) Try it I think you'll love it!
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I love this product!!!!
I absolutely love this product!!! It tastes great and gives me so much energy!!! There is no need for that coffee at 2pm!!! I have a healthy tasty alternative!!