- Helps enhance and stabilize mood
- May promote calmness and relaxation
- Supports healthy sleep quality
- Promotes sleep
- Assists in releasing mental tension
- Helps to clear the mind
- Promotes normal regulation of enzyme and hormone production
- Promotes cognitive health
- Provides antioxidant protections
- Contains no gluten, wheat, soy, yeast, artificial flavor, salt, preservatives or milk
- No Detectable GMOs
- Isotonic-Capable Drinkable Supplements
It’s hard to feel balanced and grounded sometimes, especially when restless and worrying thoughts cut into your downtime. Sometimes you just need to free yourself from life’s to-do lists and halt the brakes on your ruminating mind. Bring some calmness into your life with Isotonix Essentials®.
Designed for relaxation, Isotonix Essentials® Turn Down features a custom blend of vitamins, amino acids and minerals all in one easy-to-use packet. The formula contains effective key ingredients to help you quiet down your body, promote mental clarity, control mental tension and support healthy sleep quality.
Many people can benefit from slowing down life a little. According to the American Institute of Stress, 77% of people regularly experience physical symptoms caused by stress (e.g. fatigue, headache, muscle tension); 76% regularly experience psychological symptoms caused by stress.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
Directions For Use
1. Pour contents of packet into a cup.
2. Add 8 fl. oz. of water into the cup and stir.
As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of water and powder are used.
What does Isotonix® mean?
Isotonix® dietary supplements are delivered in an isotonic liquid solution. This means that the body has less work to do in the absorption process. The isotonic state of the suspension allows nutrients to pass efficiently into the small intestine and be rapidly delivered into the bloodstream. With Isotonix® products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.*
Who should use this product?
Anyone looking for rest and relaxation support, and those looking for solutions support sleep quality affected by everyday stressors (e.g. travel, occupation, family).*
How do I take Isotonix Essentials® Turn Down?
Pour contents of packet into a cup. Add 8 fl. oz of water into the cup and stir. Maximum absorption occurs when taken on an empty stomach.
How often should I use Isotonix Essentials® Turn Down?
As a dietary supplement, take once daily or as directed by your healthcare provider.
When should I take Isotonix Essentials® Turn Down?
Take this product when you are looking for moments of stress relief and relaxation.
How is Isotonix Essentials® Turn Down different from other similar products on the market?
Isotonix Essentials® Turn Down knows you need the building blocks to feel refreshed, and that is why we offer a blend of minerals and amino acids that support rest and relaxation.* Our Turn Down formula helps enhance and stabilize your mood, promote mental clarity and support a healthy sleep quality.
Are there any contraindications or warnings for this product?
If you are currently using any prescription medication or have an ongoing medical condition, you should consult your healthcare provider before using this product. Magnesium should be used cautiously in individuals with reduced kidney function due to an increased risk of hypermagnesemia. Discontinue use and consult your healthcare provider if you experience diarrhea, abdominal cramping or discomfort. If you are taking any other sleep aid, monoamine oxidase inhibitors (MAOI) or other antidepressants such as Zoloft or Paxil, psychoactive or tranquilizing drugs such as Klonopin or Valium, or pain medications such as Demerol or Ultram, you should consult your healthcare provider before using this product. Take this supplement separately from prescription drugs. Women who are pregnant or breastfeeding should not use this product.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.
L-Tryptophan: 500 mg
In the body, tryptophan is converted into 5-hydroxytryptophan, which then can be converted into serotonin. The body cannot naturally produce this amino acid; therefore, it must be a part of the diet or ingested through supplementation. Tryptophan is a component of many animal and plant proteins. Food sources of tryptophan are dairy products, beef, poultry, barley, brown rice, fish, soybeans and peanuts.*
Vitamin C (Ascorbic Acid): 604 mg
Vitamin C is found in peppers (sweet, green, red, hot red and green chili), citrus fruits and brussels sprouts, cauliflower, cabbage, kale, collards, mustard greens, broccoli, spinach, guava, kiwi fruit, currants and strawberries. Nuts and grains contain small amounts of vitamin C. It is important to note that cooking destroys vitamin C activity.
Vitamin C is integral in supporting a healthy immune system, promoting cardiovascular health, helping to maintain healthy cholesterol levels and providing an antioxidant defense. The body does not manufacture vitamin C on its own, nor does it store it. Therefore, vitamin C must be acquired through diet and supplementation.*
Potassium (Biocarbonate): 384 mg
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also supports a wide variety of biochemical and physiological processes. Among other things, potassium supports the normal transmission of nerve impulses, contraction of cardiac, skeletal and smooth muscle, synthesis of nucleic acids, maintenance of intracellular tonicity and maintenance of normal blood pressure. In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium supports normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat. Potassium supports the body’s ability to regulate water balance, recover from exercise and eliminate wastes.*
Calcium (Lactate, Carbonate, Sulfate, Citrate): 375 mg
The highest concentration of calcium is found in milk. Other foods rich in calcium include vegetables such as collard greens, Chinese cabbage, mustard greens, broccoli, bok choy and tofu. Calcium is an essential mineral with a wide range of biological roles. Calcium exists in bone primarily in the form of hydroxyapatite (Ca10 (PO4)6 (OH)2).
Hydroxyapatite accounts for approximately 40 percent of bone weight. The skeleton has a structural requisite and acts as a storehouse for calcium. Apart from being a major component of bones and teeth, calcium supports normal muscle contraction, nerve health, heart rhythms, blood coagulation, glandular secretion, energy production and immune system function.*
Sufficient daily calcium intake is necessary for maintaining optimal bone density, healthy bones and teeth and has been shown to ease the discomfort of PMS in women. When the body does not get enough calcium per day, it draws calcium from your bones.
The amount of calcium in the blood is regulated by PTH (parathyroid hormone). High levels of calcium in the body correlate with normal cardiovascular health and maintaining normal cholesterol levels. In the American Dietetic Association Journal, a study revealed that calcium helped middle-aged women to maintain healthy weight levels.*
Magnesium (Carbonate, Citrate, Glycinate, Oxide): 300 mg
Magnesium is a component of the mineralized part of bone and supports the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also promotes the normal mobilization of calcium, transporting it inside the cell for further utilization. It plays a key role in supporting the normal functioning of muscle and nervous tissue. Magnesium promotes the normal synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates.
Magnesium works together with calcium to help maintain the normal regulation of the heart and blood pressure. Importantly, magnesium also supports the body’s ability to build healthy bones and teeth, and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.*
Niacin (as Niacinamide): 20 mg NE
Niacin plays an essential role as a coenzyme (NAPH/ NADPH) for about 200 enzymes which promote normal tissue respiration, synthesis of fatty acids and steroid hormones, the metabolism of carbohydrates and amino acids, and the transport of hydrogen. When niacin levels are low, the body can use L-tryptophan to manufacture the vitamin. To produce 1 mg of niacin, the body must use 60 mg of L-tryptophan, a process which can rapidly deplete L-tryptophan levels. When niacin levels are sufficient, L-tryptophan can be used for other needs such as retaining healthy levels of serotonin.*
Vitamin B6 (Pyridoxine HCl): 4 mg
Vitamin B6 promotes the normal conduction of nerve impulses, regulation of steroid hormones, catabolism of glycogen for glucose, heme synthesis, and the synthesis/metabolism of amino acids and neurotransmitters. After conversion to pyridoxal phosphate (PLP), vitamin B6 acts as a cofactor for many enzymatic reactions involving L-tryptophan, including L-tryptophan’s conversion to serotonin.*
Riboflavin (Vitamin B2): 2.9 mg
Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. It serves as a coenzyme, working with other B vitamins. It promotes healthy red blood cell formation, supports the nervous system, respiration, antibody production and normal human growth. It supports healthy skin, nails, hair growth and promotes normal thyroid activity (a healthy thyroid is essential in maintaining a healthy weight, among other things). Vitamin B2 supports the body's ability to turn food into energy as a part of the electron transport chain, driving cellular energy on the micro-level. Riboflavin can be useful for pregnant or lactating women, as well as athletes due to their higher caloric needs. Vitamin B2 also promotes the normal breakdown of fats. Vitamin B2 is water-soluble and cannot be stored by the body except in insignificant amounts. It must be replenished daily.*
Manganese (Sulfate): .5 mg
Manganese is a mineral found in large quantities in both plant and animal matter. The most valuable dietary sources of manganese include whole grains, nuts, leafy vegetables and teas. Manganese is concentrated in the bran of grains, which is often removed during processing.
Only trace amounts of this element can be found in human tissue. Manganese is predominantly stored in the bones, liver, kidney and pancreas. It supports the normal formation of connective tissue, bones, blood-clotting factors and sex hormones. It supports normal fat and carbohydrate metabolism, calcium absorption and blood sugar regulation. Manganese also promotes normal brain and nerve function.
Manganese is a component of the antioxidant enzyme manganese superoxide dismutase (MnSOD). Antioxidants scavenge free radicals that occur naturally in the body but can possibly contribute to the aging process. Antioxidants such as MnSOD can neutralize free radicals.
Some experts estimate that as many as 37 percent of Americans do not get the recommended daily amounts of manganese in their diet. This may be due to the fact that whole grains are a major source of dietary manganese, and many Americans consume refined grains more often than whole grains. Refined grains provide half the amount of manganese as whole grains.*
Boron (Citrate): .5 mg
Boron is a mineral found at high levels in plant foods such as dried fruits, nuts, dark green, leafy vegetables, applesauce, grape juice and cooked dried beans and peas. Boron is found in most tissues, but mainly in the bone, spleen and thyroid. Boron supports normal bone and hormone metabolism. Boron supports the body’s ability to build and maintain healthy bones. It also helps retain adequate amounts of calcium and magnesium to promote proper bone mineralization. Boron is an essential cofactor for the converting vitamin D to its active form. It helps maintain healthy cell membranes, supports proper mental functioning and alertness, and supports normal serum estrogen levels and ionized calcium.*
Vitamin D3 (Cholecalciferol): 12.5 mcg (500 IU)
Regular sunlight exposure is the main way that most humans get their vitamin D. Food sources of vitamin D include vitamin D-fortified milk (100 IU per cup), cod liver oil and fatty fish such as salmon, and small amounts are found in egg yolks and liver.
Vitamin D promotes the absorption of calcium and phosphorus, and supports the production of several proteins involved in calcium absorption and storage. Vitamin D works with calcium to promote strong, hard bones. It supports normal transport of calcium out of the osteoblasts into the extra-cellular fluid and in the kidneys. It also promotes normal calcium and phosphate re-uptake through the renal tubules and intestinal epithelium. It supports normal skin cell growth and helps maintain normal production of insulin by the pancreas.*
Vitamin A (1% as Beta Carotene): 362 mcg RAE
Vitamin A is a fat-soluble vitamin. Sources of vitamin A include organ meats (such as liver and kidney), egg yolks, butter, carrot juice, squash, sweet potatoes, spinach, peaches, fortified dairy products and cod liver oil. Vitamin A is also part of a family of compounds, including retinol, retinal and beta-carotene. All the body’s tissues use Vitamin A for normal growth and repair.*
- aan het Rot, M., et al. Social behaviour and mood in everyday life: the effects of tryptophan in quarrelsome individuals. Journal of Psychiatry and Neuroscience. 31(4): 253-262, 2006.
- Allender PS, Cutler JA, Follman D, et al. Dietary calcium and blood pressure: meta—analysis of randomized clinical trials. Ann Intern Med. 1996; 124:825-831.
- Altura BM and Altura BT. Magnesium and cardiovascular biology: An important link between cardiovascular risk factors and atherogenesis. Cell Mol Biol Res. 41:347-59, 1995.
- Altura BM, Altura BT. Role of magnesium and calcium in alcohol-induced hypertension and strokes as probed by in vivo television microscopy, digital image microscopy, optical spectroscopy, 31P-NMR, spectroscopy and a unique magnesium ion-selective electrode. Alcohol Clin Exp Res. 1994; 18:1057-1068.
- Appel LJ. Nonpharmacologic therapies that reduce blood pressure: A fresh perspective. Clin Cardiol. 22:1111-5, 1999.
- Baly DL, Schneiderman JS, Garcia-Welsh AL. Effect of manganese deficiency on insulin binding, glucose transport and metabolism in rat adipocytes. J Nutr. 1990; 120:1075-1079.
- Barker J. Insomnia options; natural medicine choices. Townsend Letter for Doctors and Patients. April 2004.
- Baron JA, Beach M, Mandel JS, et al. Calcium supplements for the prevention of colorectal adenomas. N Engl J Med 1999;340:101-107.
- Baron JA, Tosteson TD, Wargovich MJ, et al. Calcium supplementation and rectal mucosal proliferation: a randomized controlled trial. J Natl Cancer Inst 1995;87:1303-1307.
- Baxter GF, Sumeray MS, Walker JM. Infant size and magnesium: insights into LIMIT-2 and ISIS-4 from experimental studies. Lancet. 1996; 348:1424-1426.
- Beattie JH, Peace HS. The influence of a low-boron diet and boron supplementation on bone, major mineral and sex steroid metabolism in postmenopausal women. Br J Nutr. 1993 May;69(3):871-84.
- Bell , C., et al. Tryptophan depletion and its implications for psychiatry. British Journal of Psychiatry. 178: 399-405, 2001.
- Bell L, Halstenson CE, Halstenson CJ, et al. Cholesterol-lowering effects of calcium carbonate in patients with mild to moderate hypercholesterolemia. Arch Intern Med. 1992; 152:2441-2444.
- Bilbey, D.L. J., et al. Muscle cramps and magnesium deficiency: case reports. Can Fam Physician. 42:1348-51, 1996.
- Booij, L., et al. Acute tryptophan depletion as a model of depressive relapse. British Journal of Psychiatry. 187: 148-154, 2005.
- Bostick RM, Kushi LH, Wu Y, et al. Relation of calcium, vitamin D, and dairy food intake to ischemic heart disease mortality among postmenopausal women. Am J Epidemiol 1999;149:151-160.
- Brilla, L. R., et al. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 11(3):326-329, 1992.
- Britton J, Pavord I, Richards K, et al. Dietary magnesium, lung function, wheezing, and airway hyper-reactivity in a random adult population sample. Lancet. 1994; 344:357-362.
- Brown R. and Gerbarg P. Herbs and nutrients in the treatment of depression, anxiety, insomnia, migraine, and obesity. J Psychiatr Pract. 7(2):75-91, 2001.
- Buckley LM, Leib ES, Cartularo KS, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. Ann Intern Med. 1996; 125:961-968.
- Caddell JL. Magnesium deficiency promotes muscle weakness, contributing to the risk of sudden infant death (SIDS) in infants sleeping prone. Magnes Res. 14(1-2):39-50, 2001. Review.
- Casscells W. Magnesium and myocardial infarction. Lancet. 1994; 343:807-809.
- Chollet D et al. Blood and brain magnesium in inbred mice and their correlation with sleep quality. Am J Physiol Regul Integr Comp Physiol. 279(6):R2173-8, 2000.
- Christiansen CW, Rieder MA, Silverstein EL, Gencheff NE. Magnesium sulfate reduces myocardial infarct size when administered before but not after coronary reperfusion in a canine model. Circulation. 1995; 92:2617-2621.
- Christin Marandino, Vegetarian Times, August 1998 Curhan GC, Willett WC, Speizer FE, et al. Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk of kidney stones in women. Ann Intern Med. 1997; 126:497-504.
- Cools, R., et al. Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity. Neuropsychopharmacology. 30:1362-1373, 2005.
- Corsonello A et al. Serum magnesium levels and cognitive impairment in hospitalized hypertensive patients. Magnes Res. 14(4):273-82, 2001.
- Dahle, L. O., et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 173(1):175-180, 1995.
- Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density on men and women 65 years of age and older. N Engl J Med. 1997; 337:670-676.
- de Lourdes Lima M, Cruz T, Carreiro Pousada J, et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care. 1998; 21:682-686.
- Del-Ben, C., et al. Serotonergic modulation of face-emotion recognition. Brazilian Journal of Medical and Biological Research. 41(4): 263-269, 2008.
- Demirkaya S et al. A comparative study of magnesium, flunarizine and amitriptyline in the prophylaxis of migraine. J Headache Pain. 1:179-86, 2000.
- Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press; 1997.
- Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res. 1994; 7:313-328.
- Elisaf M, Merkouropoulos M, Tsianos EV. Siamopoulos KC. Pathogenetic mechanisms of hypomagnesemia in alcoholic patients. J Trace Elem Med Biol. 1995; 9:210-214.
- Elisaf M, Milionis H, Siamopoulos K. Hypomagnesemic hypokalemia and hypocalcemia: Clinical and laboratory characteristics. Mineral Electrolyte Metab. 23:105-12, 1997.
- Facchinetti F, Borella P, Sances G, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol. 1991; 78:177-181.
- Garland CF, Garland FC, Gorham ED. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Ann NY Acad Sci. 1999; 889:107-119.
- Gong H, Amemiya T. Optic nerve changes in manganese-deficient rats. Exp Eye Res. 1999; 68:313-320.
- Griffiths , W., et al. Tryptophan and sleep in young adults. Psychophysiology. 9(3): 345-356, 1972.
- Gruber H et al. Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton. BMC Musculoskelet Disord. 4(1):7, 2003.
- Gullestad L, Dolva LO, Soyland E, et al. Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcohol Clin Exp Res. 1992; 16:986-990.
- Guran T et al. Cognitive and psychosocial development in children with familial hypomagnesaemia. Magnes Res. 24(1):7-12, 2011.
- Hartmann, E. and Spinweber, C. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. The Journal of Nervous and Mental Disease. 167(8): 497-499, 1979.
- Health & Medicine. (Statistical Data Included) American Fitness, July, 1999 Tannen RL. Effects of potassium on blood pressure control. Ann Intern Med. 1983; 98(part 2):773-780.
- Heaney RP. Calcium, dairy products and osteoporosis. J Am Coll Nutr. 2000; 19(2 Suppl):83S-99S.
- Hornyak M et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 21:501-5, 1998.
- Houston M. The role of magnesium in hypertension and cardiovascular disease. J Clin Hypertens (Greenwich). 13(11):843-7, 2011. Review.
- Huerta MG, Roemmich JN, Kington ML, et al. Magnesium deficiency is associated with insulin resistance in obese children. Diabetes Care. 28:1175-81, 2005.
- Huskisson E et al. The influence of micronutrients on cognitive function and performance. J Int Med Res. 35(1):1-19, 2007. Review.
- Hussain S, Ali SF. Manganese scavenges superoxide and hydroxyl radicals: an in vitro study in rats. Neuroscience Letters. 1999; 261:21-24.
- Inna Slutsky et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 65(2):165-77, 2010.
- Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
- ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulfate in 58,050 patients with suspected acute myocardial infarction. Lancet. 1995; 345:669-685.
- Jee SH et al. The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials. Am J Hypertens. 15:691-6, 2002.
- Jorde R, Sundsfjord J, Haug E, et al. Relation between low calcium intake, parathyroid hormone, and blood pressure. Hypertension 2000;35:1154-1159.
- Kao WHL, Folsom AR, Nieto J, et al. Serum and dietary magnesium and the risk for type 2 diabetes mellitus (editorial). Arch. Int Med. 1999; 159:2151-2159.
- Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese from experimental studies. Neurotoxicol. 1999; 20:213-223.
- Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
- Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol. 10:525-35, 1990.
- Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet. 1995; 346:270-274.
- LeMarquand, D., et al. Behavioral disinhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism. American Journal of Psychiatry. 156: 1771-1779, 1999.
- Lim R, Herzog WR. Magnesium for cardiac patients: is it a valuable treatment supplement? Contemp Int Med. 1998; 10:6-9.
- Lipkin M, Newmark H. Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med. 1985; 313:1381-1384.
- Lopez-Ridaura R et al. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care. 27:134-40, 2004.
- Lucas MJ, Leveno KJ, Cunningham FG. A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. N Engl J Med. 1995; 333:201-205.
- Maizels, M., et al. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Headache. 44(9):885-90, 2004.
- Martini LA. Magnesium supplementation and bone turnover. Nutr Rev. 1999; 57:227-229.
- Mauskop A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 1998; 5:24-27.
- Mauskop, A., et al. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci. 5(1):24-27, 1998.
- Meyer KA et al. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr. 71:921-30, 2000.
- Monograph. L-Tryptophan. Alternative Medicine Review. 11(1): 52-56, 2006.
- Murphy, S., et al. Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers. Psychopharmacology ( Berlin ). 187(1): 121-130, 2006.
- Naghii MR, Wall PM, Samman S. The boron content of selected foods and the estimation of its daily intake among free-living subjects. J Am Coll Nutr. 1996 Dec;15(6):614-9.
- Neumeister, A., et al. Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy. Archives of General Psychiatry. 55: 524-530, 1998.
- New SA et al. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 65:1831-9, 1997.
- Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994;102:83-85
- Nielsen FH. Studies on the relationship between boron and magnesium which possibly affects the formation and maintenance of bones. Magnes Trace Elem. 1990;9:61-69
- Nielsen FH. Ultratrace minerals. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease, 9th ed. Baltimore, MD: Williams and Wilkins; 1999:283-303.
- Oginni LM, Sharp CA, Worsfold M, et al. Healing of rickets after calcium supplementation. Lancet. 1999; 353:296-297.
- Orchard TJ. Magnesium and type 2 diabetes mellitus (editorial). Arch Int Med. 1999; 159:2119-2120.
- Paolisso G et al. Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr. 55:1161-7, 1992.
- Paolisso G, Sgamabato S, Pizza G, et al. Improved insulin response and action by chronic magnesium administration in aged NIDDM. Diabetes Care. 1989; 12:265-269.
- Peacock JM et al. Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study. Annals of Epidemiology. 9:159-65, 1999.
- Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia. 1996; 16:257-263.
- Penland J.G. The importance of boron nutrition for brain and psychological function. Biol Trace Elem Res. 1998; 66:299-317.
- Popoviciu L et al. Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency (abstract). Rom J Neurol Psychiatry. 31:55-61, 1993.
- Preuss HG, Gondal JA, Lieberman S. Association of macronutrients and energy intake with hypertension. J Am Coll Nutr. 15:21-35, 1996.
- Recker RR. Calcium absorption and achlorhydria. N Engl J Med. 1985; 313:70-73.
- Reid IR, Ames RW, Evans MC, et al. Effect of calcium supplementation on bone loss in postmenopausal women. N Engl J Med. 1993; 328:460-464.
- Rivlin RS. Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development (a review). J Am Coll Nutr. 1994; 13:416-423.
- Roberts JM. Magnesium for preeclampsia and eclampsia. N Engl J Med. 1995; 333:250-251.
- Rodriguez-Moran M and Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects. Diabetes Care. 26:1147-52, 2003.
- Roffe C, Fletcher S, Woods KL. Investigation of the effects of intravenous magnesium sulphate on cardiac rhythm in acute myocardial infarction. Br Heart J. 1994; 71:141-145.
- Roffe, C., et al. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 8(5):CR326-CR330, 2002.
- Rubinsztein, J., et al. Acute dietary tryptophan depletion impairs maintenance of affective set and delayed visual recognition in healthy volunteers. Psychopharmacology. 154: 319-326, 2001.
- Rude KR. Magnesium metabolism and deficiency. Endocrinol Metab Clin North Am. 22:377-95, 1993.
- Rude R et al. Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem. 15(12):710-716, 2004.
- Russo, S, et al. Tryptophan as a link between psychopathology and somatic states. Psychosomatic Medicine. 65: 665-671, 2003.
- Ryder K et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 53(11):1875-1880, 2005.
- Sales CH et al. Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. Clin Nutr. 30(3):359-64, 2011.
- Sanjuliani AF et al. Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients. Int J Cardiol. 56:177-83, 1996.
- Saris NE, Mervaala E, et al. Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Saris N-EL, Mervaala E, Karppanen H, et al. Magnesium. An update on physiological, clinical and analytical aspects (review). Clinica Chimica Acta. 2000; 294:1-26.
- Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
- Sato-Mito N et al. The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. Sleep Med. 12(3):289-94, 2011.
- Shechter M et al. Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease. Am J Cardiol. 91:517-21, 2003.
- Shechter M et al. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation.102:2353-58, 2000.
- Shils ME. Magnesium. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:169-192.
- Sinclair, S., et al. Migraine headaches: nutritional, botanical and other alternative approaches. Alternative Medicine Review. 4(2):86-95, 1999.
- Singh MA. Combined exercise and dietary intervention to optimize body composition in aging. Ann N Y Acad Sci. 1998 Nov 20;854:378-93.
- Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA. 2000; 283:2822-2825.
- Sojka JE. Magnesium supplementation and osteoporosis. Nutr Rev. 1995; 53:71-80. Strause L, Saltman P, Glowacki J. The effect of deficiencies of manganese and copper on osteo-induction and on resorption of bone particles in rats. Calcif Tissue Int. 1987; 41:145-150
- Song Y et al. Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care. 27:59-65, 2004.
- South, J. L-Tryptophan, natures answer to Prozac®. International Antiaging Systems (IAS) Bulletin, 2007. (http://www.antiaginsystems.com/extract/ltrypt.htm)
- Stendig-Lindberg G et al. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res. 6:155-63, 1993.
- Steritei, R. How to get a good nights sleep with tryptophan. NaturDoctor. 2007. (www.naturdoctor.com/Chapters/Research/Insomnia.pdf)
- Strause L, Saltman P, Smith KT, et al. Spinal bone loss in postmenopausal women supplemented with calcium and trace minerals. J Nutr. 1994; 124:1060-1064.
- Sutherland B, Strong P, King JC. Determining human dietary requirements for boron. Biol Trace Elem Res. 1998 Winter;66(1-3):193-204.
- Svetkey LP et al. Effects of dietary patterns on blood pressure: Subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Arch Intern Med. 159:285-93, 1999.
- Talbot JR, Guardo P, Seccia S, et al. Calcium bioavailability and parathyroid hormone acute changes after oral intake of dairy and nondairy products in healthy volunteers. Osteoporosis Int. 1999; 10:137-142.
- Tanabe, K., et al. Efficacy of oral magnesium administration on decreased exercise tolerance in a state of chronic sleep deprivation. Jpn Circ J. 62(5):341-346, 1998.
- Tanabe, K., et al. Erythrocyte magnesium and prostaglandin dynamics in chronic sleep deprivation. Clin Cardiol. 20(3):265-268, 1997.
- Tobian L. Salt and hypertension. Lessons from animal models that relate to human hypertension. Hypertension. 1991; 17:152-158.
- Tosiello L. Hypomagnesemia and diabetes mellitus. A review of clinical implications. Arch Intern Med. 1998; 156:1143-1148.
- Tranquilli AL et al. Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol. 8:55-8, 1994.
- Trauninger, A., et al. Oral magnesium load test in patients with migraine. Headache. 42(4):114-119, 2002.
- Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 69(4):727-36, 1999.
- van der Veen, F., et al. Effects of acute tryptophan depletion on mood and facial emotion perception related brain activation and performance in healthy women with and without a family history of depression. Neuropsychopharmacology. 32: 216-224, 2007.
- Voderholzer, U., et al. Impact of experimentally induced serotonin deficiency by tryptophan depletion on sleep EEG in healthy subjects. Neuropsychopharmacology 18(2): 112-124, 1998.
- Volpe SL, Taper LJ, Meacham S. The relationship between boron and magnesium status and bone mineral density in the human: a review. Magnes Res. 1993;6:291-296
- Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 24:27-37, 2003.
- Wang, F., et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache. 43(6):601-610, 2003.
- Wargovich MJ, Eng VWS, Newmark HL. Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium. Cancer Lett. 1984; 23:253-258.
- Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, MD: Williams and Wilkins; 1999:141-155.
- Wester PO. Magnesium. Am J Clin Nutr. 45:1305-12, 1987.
- Widman L et al. The dose-dependent reduction in blood pressure through administration of magnesium. A double blind placebo controlled cross-over study. Am J Hypertens. 6:41-5, 1993.
- Wolf RL, Cauley JA, Baker CE, et al. Factors associated with calcium absorption efficiency in pre- and perimenopausal women. Am J Clin Nutr. 2000; 72:466-471.
- Woods KL, Fletcher S. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet. 1994; 343:816-819.
- Woolhouse, M. Migraine and tension headache--a complementary and alternative medicine approach. Aust Fam Physician. 34(8):647-51, 2005. Review.
- Yu-Yahiro, J. A. Electrolytes and their relationship to normal and abnormal muscle function. Orthop Nurs. 13(5):38-40, 1994.
- Zemel MB, Shi H, Greer B, et al. Regulation of adiposity by dietary calcium. FASEB J. 2000; 14:1132-1138.
TURN DOWN&CALCIUM knock you down for a good sleep!
LOVE LOVE LOVE this product! together with calcium taken before your bedtime will give you a good night sleep!!!
Response from Customer Service:
March 4, 2020
Dear Valued Customer,
Thank you for taking the time to leave your thoughts on the Isotonix Essentials Turn Down! We are happy to hear you are pleased with the product.
Thank you again!
The Product Information Team
improve my sleep quality
always feel well rested after I sleep even I only had a few hours of sleep
started using this a couple of weeks ago, this is so good for a restful nights sleep. So glad I can recommend this to my family and friends and anyone who needs to just mellow out after a busy day, this does just what it says it will do.
- Shop Consultant
Calms my mind down and allows me to fall asleep faster!
Turn Down to help me fall asleep sooner
I have problems getting to bed early and know I need the sleep for my health. Taking Turn Down gives me relief and I take it one hour before bedtime. I'm ready to fall asleep by then and have a good night's sleep.