Jumpstart to a Healthier You!

Isotonix OPC-3®: The world’s most powerful antioxidant.
Prime NAD+: "NAD is the closest we've gotten to a fountain of youth."
Isotonix Magnesium: The single most influential mineral for human health.

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How Core 3 Health Benefits You

Restore, Rebuild, and Reset with Core 3 Health: three powerful products in three simple steps. Our hottest health superstars have been carefully selected for one triple-threat system for maximum effect and truly amazing results. Feel empowered as Isotonix OPC-3®, Prime Anti-Aging Nutraceuticals® NAD+ and Isotonix® Magnesium work together to help you wake up refreshed, turn back the clock on aging, fuel your physical performance and get quality sleep. Experience Core 3 Health’s powerhouse of antioxidants, critical nutrients and cutting-edge science — and finally stay healthy to your core!

  • Works synergistically for max results: Our hottest health superstars in one triple-threat system.
  • Wake up refreshed: Fill the nutritional gaps and vitamin deficiencies that are zapping your energy, disrupting your sleep and holding you back.
  • Turn back the clock: Be a healthier, more youthful you and slow the effects of aging for mental and physical vitality that rivals the Olympians.
  • Fuel peak performance: Give your body the supplements it needs for optimally functioning muscles, bones, joints, blood flow, vision and more!
  • Save. Share. Earn. We know you’ll love it, so we’re offering bonus perks.

Available with Isotonix OPC-3® in 100 g or 300 g! Choose the size that matches your lifestyle and health needs. Our Isotonix OPC-3® 300 g option is perfect for athletes, those upping their physical fitness, or people always on-the-go! 

How to Use Core 3 Health 


Take OPC-3 and the first capful of Magnesium when you wake up. Be ready to take on whatever the day throws at you.


Take NAD+ in the morning, before your midday meal. Turn back the clock to fight aging and stay energized.


Take the second capful of Magnesium before you go to bed. Drift into deep, quality rest, night after night.

Isotonix OPC-3®
The world’s most powerful antioxidant, 50 times more powerful than vitamin C and 20 times more powerful than vitamin E, for supercharged oxygen delivery, glowing skin, and a surge of vitality!

Prime Anti-Aging Nutraceuticals® NAD+
Cutting-edge science that renews cells and DNA so you are energized, mentally sharp, and look and feel younger!

Isotonix Magnesium®
Stress-busting, sleep-enhancing, heart-strengthening, and energy-activating for peak performance!

What Makes Core 3 Health Unique?

Optimized health isn’t just about supplements. It’s about a thoughtful approach to maximizing metabolism, aging with energy and supporting your vitality. It is also about supporting the body’s natural rhythm. You are a symphony of nutrient signals, sleep cues and hormonal cycles. Modern life has us ignore these biological cues, so we have fallen out of rhythm – creating disruption in our response to stress, physical and mental demands, food cravings and healthy weight. We need to rebuild from the ground up and recreate a total body approach to health and longevity. Not all supplements are created equal. You can have the best nutrients, botanicals and amino acids in your wellness supplements, but if those nutrients cannot reach the needed areas of the body and deliver the critical nutrients – concentrated and ready to do the job of healthy metabolism – then you may not get the results you are seeking. CORE 3 Health offers a 1-2-3 step regimen, created with Isotonix OPC-3, Isotonix Magnesium and Prime Anti-Aging Nutraceuticals® NAD+ to target three primary pillars of daily health.


Step one: Wake up feeling RESTORED. Isotonix OPC-3 and Isotonix Magnesium contribute to total body balance. OPC’s act like the body’s courier, delivering a healthy flow of blood to the body and, with it, oxygen to tissues. Your muscles, brain, heart and beyond depend on sufficient oxygen to sustain function. Oxygen is the linchpin in promoting the health of the cell and subsequently oxidative balance within the body. Why do you care about creating oxidative balance? Because the aging process, regular fitness, diet, detoxification and even your sleep habits all contribute to the production of free radicals that are associated with the development of metabolic and age-related concerns too many of us accept as “normal.” Excessive production of free radicals may accelerate the aging process and may even be the reason you do not wake up feeling ready to tackle your day. You have heard the saying “get up and get your blood pumping,” and that is the power of Pycnogenol®± in Isotonix OPC-3. It moves blood throughout the body and neutralizes the body of accumulated free radicals. For healthy metabolism, a balance between these two forces is needed. Too much of one creates a metabolic imbalance for the other.

Why You Need Antioxidants Now, Not Later

  1. Because most of us don’t get enough of what we need from our regular diet alone, identifying additional sources of diverse antioxidants can support normal and healthy physiological processes that occur within the body.
  2. Adequate detoxification, fitness, sleep and stress support require a balance of both free radical creation and antioxidant quenching.
  3. For optimal health, including energy, healthy body composition and cognitive health, it is important to start early and assist your cellular defense system.

You want to start your day ready to combat free radicals and eradicate factors that spend your oxygen. OPC’s are powerful free radical scavengers, and sufficient oxygen is at the root of how they work. In addition, Isotonix OPC-3 is a great source of polyphenols (a type of antioxidant found in dark berries, nuts and tree barks). Polyphenols are critical for the balance of the body’s gut metabolism as well as its response to immune and endocrine (hormonal) balance. This makes Isotonix OPC-3 pair perfectly with Isotonix Magnesium for a healthy start to your day.

Magnesium is the body’s electrician and plays a critical role in sending the right energy and nutrient signals through the body. Magnesium is involved in the creation of a healthy balance of neurotransmitters within the brain, the creation of ATP (metabolic energy) within the cell targeting healthy muscle contraction and relaxation throughout the body and support for maintaining blood pressure and blood sugar levels within healthy ranges. These are all the targets for healthy aging. While OPC’s clear the way for healthy cells by bringing oxygen to the tissue and neutralizing free radicals, magnesium is working on a “systems check” throughout the body and confirming the health of our body. Magnesium turns on systems to support healthy brain function, blood sugar balance and cardiovascular performance. 

With the introduction of OPC’s and magnesium in the morning, you send potent nutrient signals to your heart, endocrine system and muscles for optimal function. By taking these two products together in the morning you are creating a synergy for production of sufficient energy and balance of blood sugar and neurotransmitter activity. In addition, the body may process and utilize nutrients like magnesium more efficiently after an overnight fast and when taken in divided amounts during the day. 

Step two: REBUILD with Prime NAD+. NAD is the body’s architect, responsible for building a strong and well-thought-out blueprint for how your cells function and what instructions you give the rest of the body. These instructions are rooted in your DNA, and the quality of those instructions, or gene expression, is rooted in NAD production in the body. The coenzyme NAD is found in nearly every cell in our bodies. It plays a crucial role in maintaining cellular regeneration and healthy aging while supporting metabolic health in the face of aging and lifestyle factors. As we age and are exposed to metabolic stressors such as processed food, excess sugar, lack of fitness and lack of healthy sleep, our natural production of NAD declines, especially in energy-dependent cells. On the flip side, research indicates that individuals with higher health scores or healthier metabolic markers tend to have higher levels of NAD production, when compared to those with lower health scores.

NAD is the currency of energy in your body’s cells. It’s about transforming your energy, remodeling the cell for healthy aging and preserving the healthy messaging our cells received in our younger years to create or maintain a healthy body in later years. Just like your finances, investing in health today creates a better future. NAD keeps your body’s cells in proper balance: NAD drives our bodies toward optimal functioning by taking old or less functional components in a cell and recycling them; it’s like turning back the clock on aging by supporting your skin, brain and body to remain youthful. The essence of vitality and the promise of youth, Prime NAD+ delivers pure nicotinamide riboside and pterostilbene, ensuring your body receives the best in cellular care.

We need the architect to redirect our cells and their instructions to follow a healthy plan because life tends to get in the way: we overwhelm our natural rhythms, or worse, we send the wrong signals at the wrong time of the day. We ignore signals to rest our body and our brain in the pursuit of productivity. We ignore signals to eat or to stop eating. We ignore signals to sleep or exercise on a schedule. By utilizing NAD prior to our mid-day meal, we are able to support its levels in the body as well as influence the role of stress hormones like cortisol that should not be at peak values mid-day. Prolonged peaks of cortisol can disrupt the relationship between glucose and insulin. NAD plays an important role in the balance of glucose and insulin. By using Prime NAD+ in the late morning, you support ongoing activity and energy expenditure by sending a powerful signal to the cell – even when your daily health plan veers off the path.

Step three: RESET your clock with Isotonix Magnesium. Magnesium is the body’s electrician. An additional 200 mg (one capful of Isotonix Magnesium) in the evening or before bed allows the body to take steps to rewire and replenish the sleep-wake cycle for the next day. Because your body receives light and dark signals (chronobiology or circadian rhythm), it is also sensitive to deviation from regulation of light and dark signals. When we skip our signals to sleep, or keep the lights on too bright, eat late at night or take our digital devices to bed, we are disrupting a healthy rhythm in the body that is necessary for processes like reaching deep sleep, waking up with a healthy blood sugar response, hormone release, eating habits, digestion and body temperature. Magnesium also happens to be an essential nutrient. Since the body is unable to synthesize magnesium on its own, the mineral must be consumed through diet and thoughtful supplementation. If you cannot make it, you need to take it.

Why is it important to take these 3 core products for health?
OPCs (Oligomeric Proanthocyanidins), such as the ones provided in Isotonix OPC-3, are critical for neutralizing toxins found in our environment as well as those created during exercise or due to aging. In combination, Prime NAD+ and Isotonix Magnesium help fuel cellular energy and restoration. Isotonix Magnesium provides magnesium in glycine form, which acts as a driving factor for NAD activity in the body; together, they support cellular energy, help maintain DNA integrity and autophagy (the cleaning out of our cell to create space for remodeling) and quality sleep cycles. That means not only better productivity the next day, but also a body primed to take on everyday hormone stressors. These three products were meticulously designed to meet our body's needs, offering a path to enriched health and youthful aging. From Isotonix OPC-3's unparalleled antioxidant properties to Isotonix Magnesium's broad-spectrum health benefits and Prime NAD+'s cellular rejuvenation: this range redefines supplements. It's not just about taking supplements; it’s about creating a synergistic effect that can profoundly impact one's health and support the total body’s axis. 

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure, or prevent any disease.

†Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.

Primary Benefits

Isotonix OPC-3

  • Supports healthy levels of oxygen to the body (muscles, brain and neurotransmitters).
  • Promotes healthy nitric oxide levels.
  • Promotes healthy blood flow to the brain.
  • Supports a healthy complexion.

Prime Anti-Aging Nutraceuticals NAD+

  • Supports a healthy sleep-wake cycle.
  • May help combat the cellular aging process.
  • Promotes cognitive health.
  • Supports healthy NAD production.
  • Supports healthy mitochondrial function.

Isotonix Magnesium

  • Helps maintain normal blood sugar levels.
  • Supports a healthy sleep quality.
  • Helps maintain normal blood pressure.

Key Ingredients

Isotonix OPC-3

Grape Seed Extract (25 mg)
Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to help maintain healthy cholesterol levels.*

Red Wine Extract (25 mg)
Red wine extract is a powerful antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.* In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.*

Pine Bark Extract (Pycnogenol®) (25 mg)
Pycnogenol®± is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all-natural combination of procyanidins, bioflavonoids and organic acids. The extract has three basic properties – it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels.*

As one of the most potent natural scavengers of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.*

Bilberry Extract (25 mg)
Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.*

Citrus Extract (Bioflavonoids) (25 mg)
Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health and help maintain healthy circulation by strengthening capillaries, arteries and veins.*

Prime Anti-Aging Nutraceuticals NAD+

Nicotinamide Riboside (crystalline nicotinamide riboside chloride)
Nicotinamide adenine dinucleotide (NAD) levels naturally decline as we age, and lower levels have been linked to various health issues and the aging process itself. Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD. When consumed, NR undergoes a series of biochemical reactions, transforming into nicotinamide mononucleotide (NMN), which the body then readily converts into NAD. NAD is a critical coenzyme found in every cell of the body. Its role is to act as a shuttle bus, carrying electrons between molecules in essential steps for many metabolic processes within the cell, namely ATP production – the energy source fueling various cellular functions.

Pterostilbene is a naturally occurring compound synthesized in plants. It has a similar structure to the more well-known phenol resveratrol. However, pterostilbene has a longer half-life and the compound has two methoxy groups, giving it a higher bioavailability than resveratrol. Once ingested, it is absorbed into the bloodstream and interacts with various cells and tissues, assisting in several biological pathways. Like resveratrol, pterostilbene has been shown to exhibit antioxidant properties, helping to neutralize harmful free radicals and oxidative stress.

Isotonix Magnesium

Magnesium (Citrate & Glycinate) (400 mg)
Magnesium is a component of the mineralized part of bone and supports the normal metabolism of potassium and calcium in adults. It helps maintain normal levels of potassium, phosphorus, calcium, adrenaline and insulin. It also promotes the normal mobilization of calcium, transporting it inside the cell for further utilization. It plays a key role in supporting the normal functioning of muscle and nervous tissue. Magnesium promotes the normal synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates.

Magnesium works together with calcium to help maintain the normal regulation of the heart and blood pressure. Importantly, magnesium also supports the body’s ability to build healthy bones and teeth and promotes proper muscle development. It works together with calcium and vitamin D to help keep bones strong. Magnesium also promotes cardiovascular health by supporting normal platelet activity and helping to maintain normal cholesterol levels.

Potassium (Bicarbonate) (150 mg)
Potassium is an electrolyte stored in the muscles. Foods rich in potassium include bananas, oranges, cantaloupe, avocado, raw spinach, cabbage and celery. Potassium is an essential macromineral that helps maintain fluid balance in the body. It also supports a wide variety of biochemical and physiological processes. Among other things, potassium supports the normal transmission of nerve impulses, contraction of cardiac, skeletal and smooth muscle, synthesis of nucleic acids, maintenance of intracellular tonicity and maintenance of normal blood pressure. In 1928, it was first suggested that high potassium intake could help maintain cardiovascular health. Potassium supports normal muscle relaxation and insulin release. It also promotes glycogen and protein synthesis. Potassium is an electrolyte that promotes normal heartbeat. Potassium supports the body’s ability to regulate water balance, recover from exercise and eliminate wastes.

±Pycnogenol® is a registered trademark of Horphag Research, Ltd.


  1. When is the most optimal time to take these products?
    There are suggested times to take products to increase effectiveness. Core 3 Health is designed as a three-step daily system. Step 1: When you wake up, take one serving of Isotonix® OPC-3 and one serving of Isotonix Magnesium. Step 2: Four to five hours later, take a serving of Prime NAD+. Step 3: Right before bed, take another serving of Isotonix Magnesium. These supplements each have a specialized part to play in your body’s health. Taking them as a 1-2-3 system will maximize the benefits to your health.

  2. What is the advantage to taking this trifecta of products regularly?
    Making Core 3 Health part of your daily routine helps regulate your circadian rhythm. Healthy circadian rhythms promote metabolic health, may support healthy sleep and may help combat the cellular aging process.

  3. Why is there sugar in Isotonix products?
    The sugars found in the Isotonix line help to make sure the solution is isotonic (similar to your body’s natural fluids). Being isotonic, it improves the delivery of nutrients to absorption sites to maximize the absorption into the bloodstream. Our unique Isotonix delivery system is designed to ensure maximum absorption, targeting aging right at its core—inside every cell and within the gut. 

  4. Does Core 3 Health still work even if I work second or third shift?
    Core 3 Health is designed to rebalance the circadian rhythm of the body. For the most part, circadian rhythm is affected by light and darkness. If you work during the nighttime, you will still follow a 1-2-3 schedule with Core 3 Health. Step 1: Take one serving of Isotonix OPC-3 and one serving of Isotonix Magnesium when you wake up. Step 2: Take Prime NAD+ 4-5 hours later. Step 3: Take another serving of Isotonix Magnesium right before you go to bed.

  5. What makes Isotonix OPC-3 unique?
    Delivered in an isotonic state, Isotonix OPC-3 is easily and quickly absorbed into the bloodstream. The combination of bilberry, grape seed and red wine extracts, as well as the clinically validated pine bark extract (Pycnogenol®) and citrus extract bioflavonoids, provides powerful antioxidant protection. Isotonix OPC-3 is a vegan formula that contains the clinically studied Pycnognenol®†, one of the most powerful natural scavengers of free radicals, which may also support cardiovascular health, maintain healthy blood vessel dilation and help maintain joint flexibility. Learn more about Isotonix OPC-3.
    †Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. patents and other international patents.

  6. What makes Isotonix Magnesium unique?
    Magnesium is a universal nutrient that is vital to the body. As an essential nutrient, magnesium needs to be replenished daily. The recommended daily value is 400 mg, and more than 50% of adults fall short of this. Isotonix® Magnesium is a vegan formula that provides a total of 400 mg of – magnesium glycinate and magnesium citrate- two highly bioavailable forms of magnesium. Both gentle on the stomach and crucial to health of the brain, our muscles and our response to glucose and insulin, stress and relaxation. Learn more about Isotonix® Magnesium.

  7. What makes Prime NAD+ unique?
    NAD, a coenzyme that is essential for carrying out cellular and metabolic functions, supports the body’s cellular regeneration process and healthy mitochondrial metabolism. Prime NAD+ delivers 250 mg of nicotinamide riboside (NR), paired with 50 mg of pterostilbene, both of which have been scientifically shown to support NAD levels within our cells. When our DNA becomes damaged, it can deplete the cell’s NAD levels, leading to a decrease in sirtuin activity. Stockpiling a healthy savings account of NAD naturally makes it easier for our cells to detoxify and aids in preserving the integrity of our genetic blueprint for optimal health. Learn more about Prime Anti-Aging Nutraceuticals® NAD+.

  8. Why are there two size options for Isotonix OPC-3®?
    Our number one selling product provides the basic foundation for detoxification, energy and physical support. Many health-concious individuals with physically demanding jobs or lifestyles see benefits from antioxidants. Our Isotonix OPC-3® 300 g option is right for people with highly active lives, those looking for antioxidant defense, or those with a higher body mass,

Product Classifications

Product Classifications

Quality Standards– GMP Operations and Standardized Ingredients

Checked For– Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency and Identity 

Gluten-Free– The finished product contains no detectible gluten (<10ppm gluten)

No Detectable GMOs– The finished product contains no detectable genetically-modified organisms.

Vegan – The product is made without ingredients produced or derived from animals.


Isotonix OPC-3

  • Cardona F, Andrés-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuño MI. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013 Aug;24(8):1415-22. doi: 10.1016/j.jnutbio.2013.05.001. PMID: 23849454.
  • Dueñas M, Muñoz-González I, Cueva C, Jiménez-Girón A, Sánchez-Patán F, Santos-Buelga C, Moreno-Arribas MV, Bartolomé B. A survey of modulation of gut microbiota by dietary polyphenols. Biomed Res Int. 2015;2015:850902. doi: 10.1155/2015/850902. Epub 2015 Feb 22. PMID: 25793210; PMCID: PMC4352430
  • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  • Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
  • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
  • Kumar Singh A, Cabral C, Kumar R, Ganguly R, Kumar Rana H, Gupta A, Rosaria Lauro M, Carbone C, Reis F, Pandey AK. Beneficial Effects of Dietary Polyphenols on Gut Microbiota and Strategies to Improve Delivery Efficiency. Nutrients. 2019 Sep 13;11(9):2216. doi: 10.3390/nu11092216. PMID: 31540270; PMCID: PMC6770155.
  • Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
  • Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
  • Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
  • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
  • Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
  • Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
  • Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
  • Williamson G, Sheedy K. Effects of Polyphenols on Insulin Resistance. Nutrients. 2020 Oct 14;12(10):3135. doi: 10.3390/nu12103135. PMID: 33066504; PMCID: PMC7602234.

Prime Anti-Aging Nutraceuticals NAD+

  • Amjad, S., Nisar, S., Bhat, A. A., Shah, A. R., Frenneaux, M. P., Fakhro, K., Haris, M., Reddy, R., Patay, Z., Baur, J., & Bagga, P. (2021). Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular metabolism, 49, 101195. https://doi.org/10.1016/j.molmet.2021.101195
  • Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews. Molecular cell biology, 22(2), 119–141. https://doi.org/10.1038/s41580-020-00313-x
  • Clement, J., Wong, M., Poljak, A., Sachdev, P., & Braidy, N. (2019). The Plasma NAD+ Metabolome Is Dysregulated in "Normal" Aging. Rejuvenation research, 22(2), 121–130. https://doi.org/10.1089/rej.2018.2077
  • Lindberg, S. (2023, May 5). Autophagy: What you need to know. Healthline. https://www.healthline.com/health/autophagy
  • ProHealth Longevity. Sirtuins and your health: the. ProHealth.com. https://www.prohealth.com/blogs/control-how-you-age/activate-your-sirtuins
  • Bsc, M. W. M. C. (2023). What foods are high in NAD. Satia - Health, Wellness, Nutrition. https://satia.com/blog/nad-why-it-matters-and-where-to-find-it
  • Billington RA, Travelli C, Ercolano E, Galli U, Roman CB, Grolla AA, Canonico PL, Condorelli F, Genazzani AA. Characterization of NAD Uptake in Mammalian Cells. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 2008 Mar 7;283(10):6367-74. 
  • Christopher R. Martens et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications volume 9, Article number: 1286 (2018). 
  • de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Zhang D, van Marken Lichtenbelt W, Schrauwen P, Schrauwen-Hinderling VB, Hesselink MKC Resveratrol and pterostilbene potently modulate autophagy. Scientific Reports. 2021. 
  • Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis. 2017;3:17. 
  • Fang, EF, Lautrup, S, Hou, Y, Demarest, TG, Croteau, DL, Mattson, MP, Bohr, VA (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 23(10), 899-916. 
  • Hanhineva K, Törrönen R, Bondia-Pons I, Pekkinen J, Kolehmainen M, Mykkänen H, Poutanen K. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. 2010 Mar 31;11(4):1365-402. doi: 10.3390/ijms11041365. PMID: 20480025; PMCID: PMC2871121.
  • Kim Y, Keogh JB, Clifton PM. Polyphenols and Glycemic Control. Nutrients. 2016 Jan 5;8(1):17. doi: 10.3390/nu8010017. PMID: 26742071; PMCID: PMC4728631.
  • Maiese K. Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer. Curr Neurovasc Res. 2017;14(3):299-304. doi: 10.2174/1567202614666170718092010. PMID: 28721811; PMCID: PMC5600856.
  • Martens, C. R., Denman, B. A., Mazzo, M. R., et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults Nature Communications. 2018. 
  • Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PloS one, 7(7), e42357. 
  • Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 Axis in Aging. Rejuvenation Res. 2017 Jun;20(3):244-247. doi: 10.1089/rej.2017.1980. PMID: 28537485. 
  • Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New insights into dietary pterostilbene: Sources, metabolism, and health promotion effects. Molecules. 2022 Sep 25;27(19):6316. 
  • Chini CC, Zeidler JD, Kashyap S, Warner G, Chini EN. Evolving concepts in NAD+ metabolism. Cell metabolism. 2021 Jun 1;33(6):1076-87. 
  • Estrela JM, Ortega A, Mena S, Rodriguez ML, Asensi M. Pterostilbene: biomedical applications. Critical reviews in clinical laboratory sciences. 2013 May 1;50(3):65-78. 

Isotonix Magnesium

  • Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
  • Wester PO. Magnesium. Am J Clin Nutr. 45:1305-12, 1987.
  • Saris NE, Mervaala E, et al. Magnesium: an update on physiological, clinical, and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
  • Vormann J. Magnesium: nutrition and metabolism. Molecular Aspects of Medicine. 24:27-37, 2003.
  • Rude KR. Magnesium metabolism and deficiency. Endocrinol Metab Clin North Am. 22:377-95, 1993.
  • Kobrin SM and Goldfarb S. Magnesium Deficiency. Semin Nephrol. 10:525-35, 1990.
  • Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 69(4):727-36, 1999.
  • Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press. Washington, DC, 1999.
  • New SA et al. Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr. 65:1831-9, 1997.
  • Gruber H et al. Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton. BMC Musculoskelet Disord. 4(1):7, 2003.
  • Ryder K et al. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc. 53(11):1875-1880, 2005.
  • Rude R et al. Magnesium deficiency and osteoporosis: animal and human observations. J Nutr Biochem. 15(12):710-716, 2004.
  • Bilbey, D.L. J., et al. Muscle cramps and magnesium deficiency: case reports. Can Fam Physician. 42:1348-51, 1996.
  • Dahle, L. O., et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 173(1):175-180, 1995.
  • Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
  • Serizawa N, Nishimuta M, Kodama N, Shimada M, Yoshitake Y, Hongu N, Ota M, Yano T. Salt Restriction Affects the Excretions of Minerals (Na, K, Ca, Mg, P and Zn) in the Second Voided Fasting Early Morning Urine. J Nutr Sci Vitaminol (Tokyo). 2019;65(2):142-147. doi: 10.3177/jnsv.65.142. PMID: 31061282.
  • Yamanaka R, Tabata S, Shindo Y, Hotta K, Suzuki K, Soga T, Oka K. Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress. Sci Rep. 2016 Jul 26;6:30027. doi: 10.1038/srep30027. PMID: 27458051; PMCID: PMC4960558.
  • Dmitrašinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S. ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation. J Med Biochem. 2016 Nov 2;35(4):375-384. doi: 10.1515/jomb-2016-0021. PMID: 28670189; PMCID: PMC5471632
  • Yu-Yahiro, J. A. Electrolytes and their relationship to normal and abnormal muscle function. Orthop Nurs. 13(5):38-40, 1994.
  • Brilla, L. R., et al. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 11(3):326-329, 1992.
  • Sato-Mito N et al. The midpoint of sleep is associated with dietary intake and dietary behavior among young Japanese women. Sleep Med. 12(3):289-94, 2011.
  • Saris, N.-E. L., et al. Magnesium: an update on physiological, clinical and analytical aspects. Clinica Chimica Acta. 294:1-26, 2000.
  • Huskisson E et al. The influence of micronutrients on cognitive function and performance. J Int Med Res. 35(1):1-19, 2007. Review.
  • Inna Slutsky et al. Enhancement of Learning and Memory by Elevating Brain Magnesium. Neuron. 65(2):165-77, 2010.
  • Arab A, Rafie N, Amani R, Shirani F. The Role of Magnesium in Sleep Health: a Systematic Review of Available Literature. Biol Trace Elem Res. 2023 Jan;201(1):121-128. doi: 10.1007/s12011-022-03162-1. Epub 2022 Feb 19. PMID: 35184264.

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Displaying reviews 1 - 5 of 17

by CharlesN

  • Shop Consultant
My product review

It's great fast acting I would give this product a five star rating basis on its effectiveness quality ability to go to work instantly help with my over all energy and over all absorb ability

Response from Customer Service:

Dear Valued Customer,

Thank you for your excellent review of our Core 3 Health product. We're overjoyed to learn that you find our product has positively supported your energy levels. Your five-star rating and detailed appraisal are invaluable to us. Thank you for your trust and for sharing your experience!

Thank you again,
The Product Information Team


  • Shop Consultant
Core 3 Health

I love my Core 3 Health! I sleep very well at night.

Response from Customer Service:

Dear Valued Customer,

We're thrilled to hear that you're enjoying the Core 3 Health and that it's supporting your sleep! Your satisfaction is important to us. If you have any questions or need assistance, feel free to reach out. Thank you for sharing your feedback!

Thank you again,
The Product Information Team

by BartR

  • Shop Consultant
Core3 Health

This has been the icing on the cake as far as my overall health is concerned. I have been on various isotonics but this sends it through the goalpost! Will never be without it!!

Response from Customer Service:

Dear Valued Customer,

Thank you for your review of nutraMetrix® Core 3 Health! We're thrilled to hear that our products have had such a positive impact on your overall health. Your feedback is invaluable to us. If you have any further feedback or questions, feel free to reach out.

Thank you again!
The Product Information Team

by ReneeB

  • Shop Consultant
The results are very good

Love the clarity I have with the products

Response from Customer Service:

Dear Valued Customer,

It's great to hear that you appreciate the clarity you experience with the Core 3 Health. We're delighted to learn about the changes you've noticed in your health. If you have any questions or need further assistance, feel free to reach out to us anytime. We're here to help!

Thank you again!
The Product Information Team


  • Shop Consultant
Great trio of products

Taking these at the suggested times has given me more energy in the day!

Response from Customer Service:

Dear Valued Customer,

Thank you for sharing your feedback! We're thrilled to hear that the Core 3 Health has helped boost your energy levels throughout the day. Our team is dedicated to providing products that support your overall well-being. If you have any questions or need further assistance, feel free to reach out to us. We appreciate your support!

Thank you again,
The Product Information Team